BROWSE

Related Researcher

Author's Photo

Bhak, Jong
KOrean GenomIcs Center(KOGIC)
Research Interests
  • Geromics, genomics, bioinformatics, protein Engineering, OMICS

ITEM VIEW & DOWNLOAD

Large-scale co-evolution analysis of protein structural interlogues using the global protein structural interactome map (PSIMAP)

Cited 32 times inthomson ciCited 33 times inthomson ci
Title
Large-scale co-evolution analysis of protein structural interlogues using the global protein structural interactome map (PSIMAP)
Other Titles
Large-scale co-evolution analysis of protein structural interlogues using the global protein structural interactome map (PSIMAP).
Author
Kim, Wan K.Bolser, Dan M.Bhak, Jong Hwa
Keywords
LIGAND-RECEPTOR PAIRS; SACCHAROMYCES-CEREVISIAE; YEAST; CONSERVATION; SEQUENCES; COMPLEXES; SITES; TREES
Issue Date
2004-05
Publisher
OXFORD UNIV PRESS
Citation
BIOINFORMATICS, v.20, no.7, pp.1138 - 1150
Abstract
Motivation: Interacting pairs of proteins should co-evolve to maintain functional and structural complementarity. Consequently, such a pair of protein families shows similarity between their phylogenetic trees. Although the tendency of co-evolution has been known for various ligand-receptor pairs, it has not been studied systematically in the widest possible scope. We investigated the degree of co-evolution for more than 900 family pairs in a global protein structural interactome map (PSIMAP-a map of all the structural domain-domain interactions in the PDB). Results: There was significant correlation in 45% of the total SCOPs Family level pairs, rising to 78% in 454 reliable family interactions. Expectedly, the intra-molecular interactions between protein families showed stronger co-evolution than inter-molecular interactions. However, both types of interaction have a fundamentally similar pattern of co-evolution except for cases where different interfaces are involved. These results validate the use of co-evolution analysis with predictive methods such as PSIMAP to improve the accuracy of prediction based on 'homologous interaction'. The tendency of co-evolution enabled a nearly 5-fold enrichment in the identification of true interactions among the potential interlogues in PSIMAP. The estimated sensitivity was 79.2%, and the specificity was 78.6%
URI
Go to Link
DOI
10.1093/bioinformatics/bth053
ISSN
1367-4803
Appears in Collections:
BME_Journal Papers
Files in This Item:
Bioinformatics-2004-Kim-1138-50.pdf Download

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU