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An, Kwangjin
Advanced Nanocatalysis Lab (An Lab)
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MR tracking of transplanted cells with "positive contrast" using manganese oxide nanoparticles

Cited 97 times inthomson ciCited 97 times inthomson ci
Title
MR tracking of transplanted cells with "positive contrast" using manganese oxide nanoparticles
Author
Gilad, Assaf A.Walczak, PiotrMcMahon, Michael T.Na, Hyon BinLee, Jung HeeAn, KwangjinHyeon, TaegwhanZijl, Peter C. M. vanBulte, Jeff W. M.
Keywords
animal cell; animal tissue; article; cell population; cell proliferation; cell transplantation; cell viability; contrast enhancement; controlled study; cytotoxicity; diagnostic imaging; dose response; electroporation; glioma cell; hemisphere; in vivo study; low drug dose; nonhuman; nuclear magnetic resonance imaging; rat
Issue Date
2008-07
Publisher
WILEY-BLACKWELL
Citation
MAGNETIC RESONANCE IN MEDICINE, v.60, no.1, pp.1 - 7
Abstract
Rat glioma cells were labeled using electroporation with either manganese oxide (MnO) or superparamagnetic iron oxide (SPIO) nanoparticles. The viability and proliferation of SPIO-labeled cells (1.9 mg Fe/ml) or cells electroporated with a low dose of MnO (100 mu g Mn/ml) was not significantly different from unlabeled cells; a higher MnO dose (785 mu g Mn/ml) was found to be toxic. The cellular ion content was 0.1-0.3 pg Mn/cell and 4.4 pg Fe/cell, respectively, with cellular relaxivities of 2.5-4.8 s(-1) (RI) and 45-84 s(-1) (R-2) for MnO-labeled cells. Labeled cells (SPIO and low-dose MnO) were each transplanted in contralateral brain hemispheres of rats and imaged in vivo at 9.4T. While SPIO-labeled cells produced a strong "negative contrast" due to the increase in R-2, MnO-Iabeled cells produced "positive contrast" with an increased R-1. Simultaneous imaging of both transplants with opposite contrast offers a method for MR "double labeling" of different cell populations.
URI
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DOI
10.1002/mrm.21622
ISSN
0740-3194
Appears in Collections:
ECHE_Journal Papers
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