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An, Kwangjin
Advanced Nanocatalysis Lab (An Lab)
Research Interests
  • Nanoparticle catalytsts, catalytic activity, selectivity, and stability, strong metal-support interactions, biofuel conversion

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Synthesis and biomedical applications of hollow nanostructures

Cited 185 times inthomson ciCited 180 times inthomson ci
Title
Synthesis and biomedical applications of hollow nanostructures
Author
An, KwangjinHyeon, Taeghwan
Keywords
Biomedical applications; Drug delivery vehicle; Etching; Galvanic replacement; Hollow; Kirkendall effect; Nanoparticle; Template synthesis
Issue Date
2009-08
Publisher
ELSEVIER SCI LTD
Citation
NANO TODAY, v.4, no.4, pp.359 - 373
Abstract
Hollow nanostructures have attracted tremendous attention from researchers in various disciplines because their high surface to volume ratio and large pore volume are highly desirable for many technological applications including drug delivery system. Several colloidal synthetic methods have been used to synthesize various hollow nanostructures. These synthetic approaches are mainly categorized into four main classes according to how the hollow structure is formed: the Kirkendall effect, chemical etching, galvanic replacement, and template-mediated approach. The large pores inside the hollow nanostructures can encapsulate and release various drugs and biomolecules, while the surface of the nanostructure can be functionalized for drug targeting or bio-labeling. These features make the hollow nanostructures a unique and promising candidate as multifunctional drug delivery vehicles. This review article covers recent progress concerning the synthesis of hollow nanostructures with their sizes smaller than 200 nm and their biomedical applications including specific targeting, imaging, and controlled release of therapeutics for simultaneous diagnosis and therapy.
URI
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DOI
10.1016/j.nantod.2009.06.013
ISSN
1748-0132
Appears in Collections:
ECHE_Journal Papers
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