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An, Kwangjin
Advanced Nanocatalysis Lab (An Lab)
Research Interests
  • Nanoparticle catalytsts, catalytic activity, selectivity, and stability, strong metal-support interactions, CO2 utilization, biomass conversion, Plastic Up-cycling

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Large-Scale Synthesis of Uniform and Extremely Small-Sized Iron Oxide Nanoparticles for High-Resolution T-1 Magnetic Resonance Imaging Contrast Agents

Cited 194 times inthomson ciCited 179 times inthomson ci
Title
Large-Scale Synthesis of Uniform and Extremely Small-Sized Iron Oxide Nanoparticles for High-Resolution T-1 Magnetic Resonance Imaging Contrast Agents
Author
Kim, Byung HyoLee, NohyunKim, HyoungsuAn, KwangjinPark, Yong IlChoi, YoonseokShin, KwangsooLee, YoujinKwon, Soon GuNa, Hyon BinPark, Je-GeunAhn, Tae-YoungKim, Young-WoonMoon, Woo KyungChoi, Seung HongHyeon, Taeghwan
Keywords
Blood pool; Circulation time; Clinical settings; Contrast agent; High resolution; High-resolution imaging; Hydrophobic nanoparticles; In-vivo; Iron oxide nanoparticle; Large scale synthesis; Maghemites; Magnetic resonance imaging contrast agents; MR imaging; MRI contrast agents; Oleyl alcohol; Phosphine oxide; Reaction temperature; Relaxivity; Spin-canting; Toxic response; Valence electron; Water dispersible; XRD patterns
Issue Date
2011-08
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.133, no.32, pp.12624 - 12631
Abstract
Uniform and extremely small-sized iron oxide nanoparticles (ESIONs) of < 4 nm were synthesized via the thermal decomposition of iron-oleate complex in the presence of oleyl alcohol. Oleyl alcohol lowered the reaction temperature by reducing iron-oleate complex, resulting in the production of small-sized nanoparticles. XRD pattern of 3 nm-sized nanoparticles revealed maghemite crystal structure. These nanoparticles exhibited very low magnetization derived from the spin-canting effect. The hydrophobic nanoparticles can be easily transformed to water-dispersible and biocompatible nanoparticles by capping with the poly(ethylene glycol)-derivatized phosphine oxide (PO-PEG) ligands. Toxic response was not observed with Fe concentration up to 100 μg/mL in MTT cell proliferation assay of POPEG-capped 3 nm-sized iron oxide nanoparticles. The 3 nm-sized nanoparticles exhibited a high r 1 relaxivity of 4.78 mM -1 s -1 and low r 2/r 1 ratio of 6.12, demonstrating that ESIONs can be efficient T 1 contrast agents. The high r 1 relaxivities of ESIONs can be attributed to the large number of surface Fe 3+ ions with 5 unpaired valence electrons. In the in vivo T 1-weighted magnetic resonance imaging (MRI), ESIONs showed longer circulation time than the clinically used gadolinium complex-based contrast agent, enabling high-resolution imaging. High-resolution blood pool MR imaging using ESIONs enabled clear observation of various blood vessels with sizes down to 0.2 mm. These results demonstrate the potential of ESIONs as T 1 MRI contrast agents in clinical settings. © 2011 American Chemical Society.
URI
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DOI
10.1021/ja203340u
ISSN
0002-7863
Appears in Collections:
ECHE_Journal Papers
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