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DC Field | Value | Language |
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dc.citation.endPage | 12542 | - |
dc.citation.number | 14 | - |
dc.citation.startPage | 12529 | - |
dc.citation.title | ONCOTARGET | - |
dc.citation.volume | 6 | - |
dc.contributor.author | Yang, Yong Ryoul | - |
dc.contributor.author | Kim, Dae Hyun | - |
dc.contributor.author | Seo, Young-Kyo | - |
dc.contributor.author | Park, Dohyun | - |
dc.contributor.author | Jang, Hyun-Jun | - |
dc.contributor.author | Choi, Soo Youn | - |
dc.contributor.author | Lee, Yong Hwa | - |
dc.contributor.author | Lee, Gyun Hui | - |
dc.contributor.author | Nakajima, Kazuki | - |
dc.contributor.author | Taniguchi, Naoyuki | - |
dc.contributor.author | Kim, Jung-Min | - |
dc.contributor.author | Choi, Eun-Jeong | - |
dc.contributor.author | Moon, Hyo Youl | - |
dc.contributor.author | Kim, Il Shin | - |
dc.contributor.author | Choi, Jang Hyun | - |
dc.contributor.author | Lee, Ho | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.contributor.author | Cocco, Lucio | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.date.accessioned | 2023-12-22T01:14:50Z | - |
dc.date.available | 2023-12-22T01:14:50Z | - |
dc.date.created | 2015-07-27 | - |
dc.date.issued | 2015-05 | - |
dc.description.abstract | O-GlcNAcylation is a reversible post-translational modification. O-GlcNAc addition and removal is catalyzed by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), respectively. More recent evidence indicates that regulation of O-GlcNAcylation is important for inflammatory diseases and tumorigenesis. In this study, we revealed that O-GlcNAcylation was increased in the colonic tissues of dextran sodium sulfate (DSS)-induced colitis and azoxymethane (AOM)/DSS-induced colitis-associated cancer (CAC) animal models. Moreover, the O-GlcNAcylation level was elevated in human CAC tissues compared with matched normal counterparts. To investigate the functional role of O-GlcNAcylation in colitis, we used OGA heterozygote mice, which have an increased level of O-GlcNAcylation. OGA+/- mice have higher susceptibility to DSS-induced colitis than OGA+/+ mice. OGA +/- mice exhibited a higher incidence of colon tumors than OGA+/+ mice. In molecular studies, elevated O-GlcNAc levels were shown to enhance the activation of NF-κB signaling through increasing the binding of RelA/p65 to its target promoters. We also found that Thr-322 and Thr352 in the p65- O-GlcNAcylation sites are critical for p65 promoter binding. These results suggest that the elevated O-GlcNAcylation level in colonic tissues contributes to the development of colitis and CAC by disrupting regulation of NF-κB-dependent transcriptional activity. | - |
dc.identifier.bibliographicCitation | ONCOTARGET, v.6, no.14, pp.12529 - 12542 | - |
dc.identifier.doi | 10.18632/oncotarget.3725 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.scopusid | 2-s2.0-84930012265 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/12773 | - |
dc.identifier.url | http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=3725&pubmed-linkout=1 | - |
dc.identifier.wosid | 000359008200058 | - |
dc.language | 영어 | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.title | Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signaling | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Oncology; Cell Biology | - |
dc.relation.journalResearchArea | Oncology; Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | O-GlcNAcylation | - |
dc.subject.keywordAuthor | O-GlcNAcase | - |
dc.subject.keywordAuthor | colitis | - |
dc.subject.keywordAuthor | colitis-associated cancer | - |
dc.subject.keywordPlus | GLCNAC TRANSFERASE | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | BOWEL-DISEASE | - |
dc.subject.keywordPlus | INTESTINAL TUMORIGENESIS | - |
dc.subject.keywordPlus | IKK-BETA | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | COLITIS | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | ACETYLGLUCOSAMINE | - |
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