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DC Field | Value | Language |
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dc.citation.endPage | 1446 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1435 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 338 | - |
dc.contributor.author | Ahn, Jeongeun | - |
dc.contributor.author | Ko, Myung Gon | - |
dc.contributor.author | Lee, Kyuyoung | - |
dc.contributor.author | Oh, Jaehak | - |
dc.contributor.author | Jeon, Sungho | - |
dc.contributor.author | Seong, Rho H | - |
dc.date.accessioned | 2023-12-22T10:10:24Z | - |
dc.date.available | 2023-12-22T10:10:24Z | - |
dc.date.created | 2015-07-24 | - |
dc.date.issued | 2005-12 | - |
dc.description.abstract | SRG3, a mouse homolog of yeast SW13 and human BAF155, is known to be a core component of SWI/SNF chromatin-remodeling complex. We have previously shown that SRG3 plays essential roles in early mouse embryogenesis, brain development, and T-cell development. SRG3 gene expression was differentially regulated depending on the developmental stages and exhibited tissue-specific pattern. In this study, we showed that the functional interactions between Sp and Ets family transcription factors are crucial for the SRG3 expression. Sp I and Sp3 specifically bound to the two canonical Sp-binding sites (GC boxes) at -152 and -114, and a non-canonical Sp-binding site (CCTCCT inotif) at -108 in the SRG3 promoter. Using Drosophila SL2 cells, we found that Various Sp or Ets family members activate the SRG3 promoter through these Sp- or Ets-binding sites, respectively, in a dose-dependent manner. Intriguingly, different combinatorial expression of Ets and Sp factors in SL2 cells resulted in either strong synergistic activation or repression of the SRG3 promoter activity. Moreover, the Sp-mediated activation of SRG3 promoter required the intact Ets-binding element. Taken together, these results Suggest that diverse interactions between Sp1/Sp3 and Ets factors are crucial for the SRG3 gene expression. (c) 2005 Elsevier Inc. All rights reserved. | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.338, no.3, pp.1435 - 1446 | - |
dc.identifier.doi | 10.1016/j.bbrc.2005.10.107 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.scopusid | 2-s2.0-27744510731 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/12653 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X05023594# | - |
dc.identifier.wosid | 000233710100018 | - |
dc.language | 영어 | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Expression of SRG3, a core component of mouse SWI/SNF chromatin-remodeling complex, is regulated by cooperative interactions between Sp1/Sp3 and Ets transcription factors | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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