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DC Field | Value | Language |
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dc.citation.endPage | 11934 | - |
dc.citation.number | 18 | - |
dc.citation.startPage | 11924 | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 283 | - |
dc.contributor.author | Oh, Jaehak | - |
dc.contributor.author | Sohn, Dong H | - |
dc.contributor.author | Ko, Myung Gon | - |
dc.contributor.author | Chung, Heekyung | - |
dc.contributor.author | Jeon, Sungho | - |
dc.contributor.author | Seong, Rho H | - |
dc.date.accessioned | 2023-12-22T08:40:22Z | - |
dc.date.available | 2023-12-22T08:40:22Z | - |
dc.date.created | 2015-07-24 | - |
dc.date.issued | 2008-05 | - |
dc.description.abstract | To understand the tumor-suppressing mechanism of the SWI/SNF chromatin remodeling complex, we investigated its molecular relationship with p53. Using the pREP4-luc episomal reporter, we first demonstrated that p53 utilizes the chromatin remodeling activity of the SWI/SNF complex to initiate transcription from the chromatin-structured promoter. Among the components of the SWI/SNF complex, we identified BAF60a as a mediator of the interaction with p53 by the yeast two-hybrid assay. p53 directly interacted only with BAF60a, but not with other components of the SWI/SNF complex, such as BRG1, SRG3, SNF5, or BAF57. We found out that multiple residues at the amino acid 108-150 region of BAF60a were involved in the interaction with the tetramerization domain of p53. The N-terminal fragment of BAF60a containing the p53-interacting region as well as small interfering RNA for baf60a inhibited the SWI/SNF complex-mediated transcriptional activity of p53. The uncoupling of p53 with the SWI/SNF complex resulted in the repression of both p53-dependent apoptosis and cell cycle arrest by the regulation of target genes. These results suggest that the SWI/SNF chromatin remodeling complex is involved in the suppression of tumors by the interaction with p53. © 2008 by The American Society for Biochemistry and Molecular Biology, Inc. | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.283, no.18, pp.11924 - 11934 | - |
dc.identifier.doi | 10.1074/jbc.M705401200 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.scopusid | 2-s2.0-45549083688 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/12641 | - |
dc.identifier.url | http://www.jbc.org/content/283/18/11924.long | - |
dc.identifier.wosid | 000255340000008 | - |
dc.language | 영어 | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.title | Baf60a interacts with p53 to recruit the SWI/SNF complex | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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