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Jeong, Hoon Eui
Multiscale Biomimetics & Manufacturing Lab
Research Interests
  • Biomimetics
  • Multiscale manufacturing
  • Micro/nanofabrication

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Fabrication of non-biofouling polyethylene glycol micro- and nanochannels by ultraviolet-assisted irreversible sealing

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Title
Fabrication of non-biofouling polyethylene glycol micro- and nanochannels by ultraviolet-assisted irreversible sealing
Other Titles
Fabrication of non-biofouling polyethylene glycol micro- and nanochannels by ultraviolet-assisted irreversible sealing
Author
Kim, PilnamJeong, Hoon EuiKhademhosseini, AliSuh, Kahp Y.
Keywords
MICROFLUIDIC DEVICE FABRICATION; PHOTOLITHOGRAPHIC POLYMERIZATION CLIPP; CAPILLARY-ELECTROPHORESIS; SURFACE MODIFICATION; SILICON SURFACES; SYSTEMS; CHANNELS; POLY(DIMETHYLSILOXANE); FLUORESCENCE; PROTEINS
Issue Date
2006-08
Publisher
ROYAL SOC CHEMISTRY
Citation
LAB ON A CHIP, v.6, no.11, pp.1432 - 1437
Abstract
We present a simple and widely applicable method to fabricate micro- and nanochannels comprised entirely of crosslinked polyethylene glycol ( PEG) by using UV- assisted irreversible sealing to bond partially crosslinked PEG surfaces. The method developed here can be used to form channels as small as similar to 50 nm in diameter without using a sophisticated experimental setup. The manufactured channel is a homogeneous conduit made completely from non-biofouling PEG, exhibits robust sealing with minimal swelling and can be used without additional surface modification chemistries, thus significantly enhancing reliability and durability of microfluidic devices. Furthermore, we demonstrate simple analytical assays using PEG microchannels combined with patterned arrays of supported lipid bilayers ( SLBs) to detect ligand ( biotin) receptor ( streptavidin) interactions
URI
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DOI
10.1039/b610503c
ISSN
1473-0197
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