Real-time label-free quantitative monitoring of biomolecules without surface binding by floating-gate complementary metal-oxide semiconductor sensor array integrated with readout circuitry
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- Real-time label-free quantitative monitoring of biomolecules without surface binding by floating-gate complementary metal-oxide semiconductor sensor array integrated with readout circuitry
- Kim, Seong-Jin; Yoo, Kyutae; Shim, Jeoyoung; Chung, Wonseok; Ko, Christopher; Im, Maesoon; Kim, Lee-Sup; Yoon, Euisik
- Issue Date
- AMER INST PHYSICS
- APPLIED PHYSICS LETTERS, v.91, pp.203903
- We report a label-free field-effect sensing array integrated with complementary metal-oxide semiconductor (CMOS) readout circuitry to detect the surface potential determined by the negative charge in DNA molecules. For real-time DNA quantification, we have demonstrated the measurements of DNA molecules without immobilizing them on the sensing surface which is composed of an array of floating-gate CMOS transistors. This nonimmobilizing technique allows the continuous monitoring of the amount of charged molecules by injecting DNA solutions sequentially. We have carried out the real-time quantitative measurement of 19 bp oligonucleotides and analyzed its sensitivity as a function of pH in buffer solutions. (c) 2007 American Institute of Physics.
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