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Ryu, Ja-Hyoung
Supramolecular NanoMaterials Lab (SUN)
Research Interests
  • Supramolecular assembly, synthetic peptide assembly, cancer drug delivery

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Tunable bacterial agglutination and motility inhibition by self-assembled glyco-nanoribbons

Cited 22 times inthomson ciCited 19 times inthomson ci
Title
Tunable bacterial agglutination and motility inhibition by self-assembled glyco-nanoribbons
Other Titles
Tunable bacterial agglutination and motility inhibition by self-assembled glyco-nanoribbons
Author
Lim, Yong-BeomPark, SomiLee, EunjiRyu, Ja-HyoungYoon, You-RimKim, Tae-HyunLee, Myongsoo
Issue Date
2007-09
Publisher
WILEY-V C H VERLAG GMBH
Citation
CHEMISTRY-AN ASIAN JOURNAL, v.2, no.11, pp.1363 - 1369
Abstract
We explored a method of controlling bacterial motility and agglutination by using self-assembled carbohydrate-coated beta-sheet nanoribbons. To this aim, we synthesized triblock peptides that consist of a carbohydrate, a polyethylene glycol (PEG) spacer, and a beta-sheet-forming peptide. An investigation into the effect of PEG-spacer length on the self-assembly of the triblock peptides showed that the PEG should be of sufficiently length to stabilize the beta-sheet nanoribbon structure. It was found that the stabilization of the nanoribbon led to stronger activity in bacterial motility inhibition and agglutination, thus suggesting that antibacterial activity can be controlled by the stabilization strategy. Furthermore, another level of control over bacterial motility and agglutination was attained by co-assembly of bacteria-specific and -nonspecific supramolecular building blocks. The nanoribbon specifically detected bacteria after the encapsulation of a fluorescent probe. Moreover, the detection sensitivity was enhanced by the formation of bacterial clusters. All these results suggest that the carbohydrate-coated P-sheet nanoribbons can be developed as promising agents for pathogen capture, inactivation, and detection, and that the activity can be controlled at will
URI
https://scholarworks.unist.ac.kr/handle/201301/12130
URL
http://onlinelibrary.wiley.com/doi/10.1002/asia.200700163/abstract
DOI
10.1002/asia.200700163
ISSN
1861-4728
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CHM_Journal Papers
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