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Rhee, Hyun-Woo
Biomimetic Chemistry Lab
Research Interests
  • Site-Specific Protein Labeling in Living Cells
  • Artificial Cofactors for Biomimetic Catalyst
  • Spatiotemporal Proteome mapping of living cells

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Label-free fluorescent real-time monitoring of adenylyl cyclase

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Title
Label-free fluorescent real-time monitoring of adenylyl cyclase
Other Titles
Label-free fluorescent real-time monitoring of adenylyl cyclase
Author
Rhee, Hyun-WooKim, Kyoung-ShimHan, Pyung-LimHong, Jong-In
Keywords
PYROPHOSPHATE SENSOR; CYCLIC-AMP; CHEMOSENSOR; ATP; WATER; DERIVATIVES; COMPLEX; ASSAY
Issue Date
2010-02
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.3, pp.1145 - 1147
Abstract
In cellular signaling, adenylyl cyclase plays a key role in the hydrolysis of ATP to cyclic AMP and pyrophosphate. Using a synthetic fluorescent chemosensor (PyDPA) which binds strongly to the pyrophosphate group, we have developed a label-free fluorescent real-time detection system for adenylyl cyclase. This assay would be the first adenylyl cyclase assay based on chemosensing the production of pyrophosphate. (C) 2009 Elsevier Ltd. All rights reserved
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DOI
10.1016/j.bmcl.2009.12.018
ISSN
0960-894X
Appears in Collections:
PHY_Journal Papers
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