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Soper, Steven A.
Soper Research Group
Research Interests
  • Micro- and nano-fabrication
  • Lab-on-a-chip
  • Polymeric Microfluidic Devices

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Hydrodynamic shearing of DNA in a polymeric microfluidic device

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Title
Hydrodynamic shearing of DNA in a polymeric microfluidic device
Author
Nesterova, Irina V.Hupert, Mateusz L.Witek, Malgorzata A.Soper, Steven A.
Keywords
DEGRADATION; FABRICATION; CHIPS
Issue Date
2012-03
Publisher
ROYAL SOC CHEMISTRY
Citation
LAB ON A CHIP, v.12, no.6, pp.1044 - 1047
Abstract
With the advent of next-generation sequencing (NGS) systems and the associated high throughput they afford, the input to these machines requires manageable lengths of fragments (similar to 1000 bp) produced from chromosomal DNAs. Therefore, it is critical to develop devices that can shear DNA in a controlled fashion. We report a polymer-based microfluidic device that establishes an efficient and inexpensive platform with performance comparable to a commercially available bench-top system.
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DOI
10.1039/c2lc21122j
ISSN
1473-0197
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BME_Journal Papers
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