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Hydrodynamic shearing of DNA in a polymeric microfluidic device

Author(s)
Nesterova, Irina V.Hupert, Mateusz L.Witek, Malgorzata A.Soper, Steven A.
Issued Date
2012-03
DOI
10.1039/c2lc21122j
URI
https://scholarworks.unist.ac.kr/handle/201301/12102
Fulltext
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84857241031
Citation
LAB ON A CHIP, v.12, no.6, pp.1044 - 1047
Abstract
With the advent of next-generation sequencing (NGS) systems and the associated high throughput they afford, the input to these machines requires manageable lengths of fragments (similar to 1000 bp) produced from chromosomal DNAs. Therefore, it is critical to develop devices that can shear DNA in a controlled fashion. We report a polymer-based microfluidic device that establishes an efficient and inexpensive platform with performance comparable to a commercially available bench-top system.
Publisher
ROYAL SOC CHEMISTRY
ISSN
1473-0197

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