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Bhak, Jong
KOrean GenomIcs Center(KOGIC)
Research Interests
  • Geromics, genomics, bioinformatics, protein Engineering, OMICS

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Insights into the Evolution of Longevity from the Bowhead Whale Genome

Cited 9 times inthomson ciCited 4 times inthomson ci
Title
Insights into the Evolution of Longevity from the Bowhead Whale Genome
Author
Keane, MichaelSemeiks, JeremyWebb, Andrew E.Li, Yang I.Quesada, VictorCraig, ThomasMadsen, Lone Bruhnvan Dam, SipkoBrawand, DavidMarques, Patricia I.Michalak, PawelKang, LinBhak, JongYim, Hyung-SoonGrishin, Nick V.Nielsen, Nynne HjortHeide-Jorgensen, Mads PeterOziolor, Elias M.Matson, Cole W.Church, George M.Stuart, Gary W.Patton, John C.George, J. CraigSuydam, RobertLarsen, KnudLopez-Otin, CarlosO'Connell, Mary J.Bickham, John W.Thomsen, Bode Magalhaes, Joao Pedro
Keywords
cycline; excision repair cross complementing protein 1; transcriptome; uncoupling protein 1
Issue Date
2015-01
Publisher
Cell Press
Citation
CELL REPORTS, v.10, no.1, pp.112 - 122
Abstract
The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis of the bowhead whale genome and two transcriptomes from different populations. Our analysis identifies genes under positive selection and bow-head-specific mutations in genes linked to cancer and aging. In addition, we identify gene gain and loss involving genes associated with DNA repair, cell-cycle regulation, cancer, and aging. Our results expand our understanding of the evolution of mammalian longevity and suggest possible players involved in adaptive genetic changes conferring cancer resistance. We also found potentially relevant changes in genes related to additional processes, including thermoregulation, sensory perception, dietary adaptations, and immune response. Our data are made available online (http://www.bowhead-whale.org) to facilitate research in this long-lived species
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DOI
10.1016/j.celrep.2014.12.008
ISSN
2211-1247
Appears in Collections:
BME_Journal Papers
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