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Park, Chan Young
Calcium Dynamics Lab
Research Interests
  • Calcium Signaling, Calcium Channels, Immune, neuroscience, Drug Development, Virus and host cell interaction.

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Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels

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dc.contributor.author Rana, Anshul ko
dc.contributor.author Yen, Michelle ko
dc.contributor.author Sadaghiani, Amir Masoud ko
dc.contributor.author Malmersjo, Seth ko
dc.contributor.author Park, Chan Young ko
dc.contributor.author Dolmetsch, Ricardo E. ko
dc.contributor.author Lewis, Richard S. ko
dc.date.available 2015-07-03T00:54:22Z -
dc.date.created 2015-07-02 ko
dc.date.issued 2015-06 ko
dc.identifier.citation JOURNAL OF CELL BIOLOGY, v.209, no.5, pp.653 - 670 ko
dc.identifier.issn 0021-9525 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/11806 -
dc.description.abstract Store-operated calcium entry (SOCE) regulates a wide variety of essential cellular functions. SOCE is mediated by STIM1 and STIM2, which sense depletion of ER Ca2+ stores and activate Orai channels in the plasma membrane. Although the amplitude and dynamics of SOCE are considered important determinants of Ca2+-dependent responses, the underlying modulatory mechanisms are unclear. In this paper, we identify STIM2β, a highly conserved alternatively spliced isoform of STIM2, which, in contrast to all known STIM isoforms, is a potent inhibitor of SOCE. Although STIM2β does not by itself strongly bind Orai1, it is recruited to Orai1 channels by forming heterodimers with other STIM isoforms. Analysis of STIM2β mutants and Orai1-STIM2β chimeras suggested that it actively inhibits SOCE through a sequence-specific allosteric interaction with Orai1. Our results reveal a previously unrecognized functional flexibility in the STIM protein family by which alternative splicing creates negative and positive regulators of SOCE to shape the amplitude and dynamics of Ca2+ signals. ko
dc.description.statementofresponsibility open -
dc.language 영어 ko
dc.publisher ROCKEFELLER UNIV PRESS ko
dc.title Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84942357590 ko
dc.identifier.wosid 000355938200004 ko
dc.type.rims ART ko
dc.description.wostc 1 *
dc.date.tcdate 2015-12-28 *
dc.identifier.doi 10.1083/jcb.201412060 ko
dc.identifier.url http://jcb.rupress.org/content/209/5/653.abstract ko
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