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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Identification of novel phosphatidic acid-binding proteins in the rat brain

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Title
Identification of novel phosphatidic acid-binding proteins in the rat brain
Author
Park, ChiHuKang, Du-SeockShin, Geon-HoonSeo, Jeong KonKim, HyeinSuh, Pann-GhillBae, Chang-DaeShin, Joo-Ho
Issue Date
2015-05
Publisher
ELSEVIER IRELAND LTD
Citation
NEUROSCIENCE LETTERS, v.595, pp.108 - 113
Abstract
Phosphatidic acid (PA) is an abundant negatively-charged phospholipid and has long been considered to be an important signaling molecule in diverse cellular events. Thus, the identification of proteins that specifically interact with PA is of considerable interest to understand the regulatory roles of PA. Herein, lipid-affinity purification and mass spectrometric analysis reveals 43 proteins, 19 known and 24 novel, as PA-binding proteins. A lipid-protein overlay assay confirmed that GDI1, PACSIN1, and DPYSL2 interact with not only with PA but also with other phospholipids. These results might be helpful for deciphering the functional effect of PA in the brain. © 2015 Elsevier Ireland Ltd
URI
https://scholarworks.unist.ac.kr/handle/201301/11543
URL
http://www.sciencedirect.com/science/article/pii/S0304394015002852#
DOI
10.1016/j.neulet.2015.04.012
ISSN
0304-3940
Appears in Collections:
BIO_Journal Papers
SE_Journal Papers
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