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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Isolation and Characterization of Fatty Acid Derivatives from an Actinomycetes and Examination of the Effects on Activities of Phospholipase C and Protein Kinase C

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Title
Isolation and Characterization of Fatty Acid Derivatives from an Actinomycetes and Examination of the Effects on Activities of Phospholipase C and Protein Kinase C
Author
Ko, Hack RyongKim, Bo-YeonLee, Hyun-SunKang, Dae-OokRyu, Sung-HoSuh, Pann-GhillMheen, Tae-IckAhn, Jong-Seong
Issue Date
1998-12
Publisher
MICROBIOLOGICAL SOCIETY KOREA
Citation
JOURNAL OF MICROBIOLOGY, v.36, no.4, pp.316 - 321
Abstract
In our screening to search inhibitors of phosphoinositide(PI)-specific phospholipase C (PI-PLC), two inhibitors, MT965-A and -B were isolated from a culture broth of an actinomycetes. MT965-A and -B were identified as fatty acid derivatives, 14-methylpentadecanoic acid and 16-methyllinoleic acid methyl ester, respectively, based on the spectral data including NMR and MS. Both inhibitors directly inhibited not only in vitro PLC gamma 1 activity but also the platelet-derived growth factor (PDGF)-induced inositol phosphates (IPt) formation in NIH 3T3 gamma 1 cells overexpressing PLC gamma 1. However, the inhibitors enhanced in, vitro protein kinase C (PKC) activity. On examination of the effects of various fatty acids (FAs) on activities of PLC, PKC, and PDGF-induced IPt formation, the unsaturated FAs (UFAs) showed the same activities like the inhibitors, but the saturated FAs (SFAs) did not show similar activities. It was inferred that the chain length, degree of unsaturation, methyl esterification, branching with a methyl group, and cis-configuration were important for their activity.
URI
https://scholarworks.unist.ac.kr/handle/201301/11482
ISSN
1225-8873
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