BROWSE

Related Researcher

Author's Photo

Cho, Hyungjoon
Biomedical Imaging Science and Engineering Lab(BISE)
Research Interests
  • Imaging tumor microenvironments, susceptibility contrast based MR structural imaging, ultra fast acquisitions of dynamic MR, algorithm/Hardware development for magnetic particle imaging

ITEM VIEW & DOWNLOAD

Robust MR assessment of cerebral blood volume and mean vessel size using SPION-enhanced ultrashort echo acquisition

Cited 0 times inthomson ciCited 0 times inthomson ci
Title
Robust MR assessment of cerebral blood volume and mean vessel size using SPION-enhanced ultrashort echo acquisition
Author
Han, SHCho, JHJung, HSSuh, JYKim, JKKim, YRCho, GCho, Hyungjoon
Issue Date
2015-05
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
NEUROIMAGE, v.112, pp.382 - 389
Abstract
Intravascular superparamagnetic iron oxide nanoparticles (SPION)-enhanced MR transverse relaxation rates ({increment}. R2 * and {increment}. R2 ) are widely used to investigate in vivo vascular parameters, such as the cerebral blood volume (CBV), microvascular volume (MVV), and mean vessel size index (mVSI, {increment}. R2 */{increment}R2 ). Although highly efficient, regional comparison of vascular parameters acquired using gradient-echo based {increment}R2 * is hampered by its high sensitivity to magnetic field perturbations arising from air-tissue interfaces and large vessels. To minimize such demerits, we took advantage of the dual contrast property of SPION and both theoretically and experimentally verified the direct benefit of replacing gradient-echo based {increment}R2 * measurement with ultra-short echo time (UTE)-based {increment}R1 contrast to generate the robust CBV and mVSI maps. The UTE acquisition minimized the local measurement errors from susceptibility perturbations and enabled dose-independent CBV measurement using the vessel/tissue {increment}R1 ratio, while independent spin-echo acquisition enabled simultaneous {increment}R2 measurement and mVSI calculation of the cortex, cerebellum, and olfactory bulb, which are animal brain regions typified by significant susceptibility-associated measurement errors. © 2015 Elsevier Inc
URI
https://scholarworks.unist.ac.kr/handle/201301/11421
URL
http://www.sciencedirect.com/science/article/pii/S1053811915002244
DOI
10.1016/j.neuroimage.2015.03.042
ISSN
1053-8119
Appears in Collections:
BME_Journal Papers
Files in This Item:
There are no files associated with this item.

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU