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Image-guided transcranial focused ultrasound stimulates human primary somatosensory cortex

Cited 4 times inthomson ciCited 3 times inthomson ci
Title
Image-guided transcranial focused ultrasound stimulates human primary somatosensory cortex
Author
Lee, WonhyeKim, HyungminJung, YujinSong, In-UkChung, Yong AnYoo, Seung-Schik
Issue Date
2015-03
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v.5, pp.1 - 10
Abstract
Focused ultrasound (FUS) has recently been investigated as a new mode of non-invasive brain stimulation, which offers exquisite spatial resolution and depth control. We report on the elicitation of explicit somatosensory sensations as well as accompanying evoked electroencephalographic (EEG) potentials induced by FUS stimulation of the human somatosensory cortex. As guided by individual-specific neuroimage data, FUS was transcranially delivered to the hand somatosensory cortex among healthy volunteers. The sonication elicited transient tactile sensations on the hand area contralateral to the sonicated hemisphere, with anatomical specificity of up to a finger, while EEG recordings revealed the elicitation of sonication-specific evoked potentials. Retrospective numerical simulation of the acoustic propagation through the skull showed that a threshold of acoustic intensity may exist for successful cortical stimulation. The neurological and neuroradiological assessment before and after the sonication, along with strict safety considerations through the individual-specific estimation of effective acoustic intensity in situ and thermal effects, showed promising initial safety profile; however, equal/more rigorous precautionary procedures are advised for future studies. The transient and localized stimulation of the brain using image-guided transcranial FUS may serve as a novel tool for the non-invasive assessment and modification of region-specific brain function
URI
https://scholarworks.unist.ac.kr/handle/201301/11101
URL
http://www.nature.com/srep/2015/150304/srep08743/full/srep08743.html
DOI
10.1038/srep08743
ISSN
2045-2322
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ETC_Journal Papers
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