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Choi, Jang Hyun
Lab of Diabetes and Metabolism Lab.
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dc.citation.endPage 448 -
dc.citation.number 3 -
dc.citation.startPage 439 -
dc.citation.title AGING CELL -
dc.citation.volume 11 - Yang, Yong Ryoul - Song, Minseok - Lee, Ho - Jeon, Yoon - Choi, Eun-Jeong - Jang, Hyun-Jun - Moon, Hyo Youl - Byun, Ha-Young - Kim, Eung-Kyun - Kim, Dae Hyun - Lee, Mi Nam - Koh, Ara - Ghim, Jaewang - Choi, Jang Hyun - Lee-Kwon, Whaseon - Kim, Kyong Tai - Ryu, Sung Ho - Suh, Pann-Ghill - 2023-12-22T05:08:07Z - 2023-12-22T05:08:07Z - 2013-10-04 - 2012-06 -
dc.description.abstract Dysregulation of O-GlcNAc modification catalyzed by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) contributes to the etiology of chronic diseases of aging, including cancer, cardiovascular disease, type 2 diabetes, and Alzheimers disease. Here we found that natural aging in wild-type mice was marked by a decrease in OGA and OGT protein levels and an increase in O-GlcNAcylation in various tissues. Genetic disruption of OGA resulted in constitutively elevated O-GlcNAcylation in embryos and led to neonatal lethality with developmental delay. Importantly, we observed that serum-stimulated cell cycle entry induced increased O-GlcNAcylation and decreased its level after release from G2/M arrest, indicating that O-GlcNAc cycling by OGT and OGA is required for precise cell cycle control. Constitutively, elevated O-GlcNAcylation by OGA disruption impaired cell proliferation and resulted in mitotic defects with downregulation of mitotic regulators. OGA loss led to mitotic defects including cytokinesis failure and binucleation, increased lagging chromosomes, and micronuclei formation. These findings suggest an important role for O-GlcNAc cycling by OGA in embryonic development and the regulation of the maintenance of genomic stability linked to the aging process. -
dc.identifier.bibliographicCitation AGING CELL, v.11, no.3, pp.439 - 448 -
dc.identifier.doi 10.1111/j.1474-9726.2012.00801.x -
dc.identifier.issn 1474-9718 -
dc.identifier.scopusid 2-s2.0-84860872762 -
dc.identifier.uri -
dc.identifier.url -
dc.identifier.wosid 000303910100009 -
dc.language 영어 -
dc.publisher WILEY-BLACKWELL -
dc.title O-GlcNAcase is essential for embryonic development and maintenance of genomic stability -
dc.type Article -
dc.description.isOpenAccess TRUE -
dc.relation.journalWebOfScienceCategory Cell Biology; Geriatrics & Gerontology -
dc.relation.journalResearchArea Cell Biology; Geriatrics & Gerontology -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor aging -
dc.subject.keywordAuthor genomic instability -
dc.subject.keywordAuthor O-GlcNAcase -
dc.subject.keywordAuthor O-GlcNAcylation -
dc.subject.keywordAuthor O-GlcNAc transferase -


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