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Soper, Steven A.
Soper Research Group
Research Interests
  • Micro- and nano-fabrication
  • Lab-on-a-chip
  • Polymeric Microfluidic Devices

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Enzymatic cleavage of uracil-containing single-stranded DNA linkers for the efficient release of affinity-selected circulating tumor cells

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Title
Enzymatic cleavage of uracil-containing single-stranded DNA linkers for the efficient release of affinity-selected circulating tumor cells
Author
Nair, Soumya V.Witek, Malgorzata A.Jackson, Joshua M.Lindell, Maria A. M.Hunsucker, Sally A.Sapp, TravisPerry, E.Hupert, Mateusz L.Bae-Jump, VictoriaGehrig, Paola A.Wysham, Weiya Z.Armistead, Paul M.Voorhees, PeterSoper, Steven A.
Issue Date
2015-02
Publisher
ROYAL SOC CHEMISTRY
Citation
CHEMICAL COMMUNICATIONS, v.51, no.15, pp.3266 - 3269
Abstract
We report a novel strategy to enzymatically release affinity-selected cells, such as circulating tumor cells (CTCs), from surfaces with high efficiency (similar to 90%) while maintaining cell viability (>85%). The strategy utilizes single-stranded DNAs that link a capture antibody to the surfaces of a CTC selection device. The DNA linkers contain a uracil residue that can be cleaved.
URI
https://scholarworks.unist.ac.kr/handle/201301/10964
URL
http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C4CC09765C#!divAbstract
DOI
10.1039/c4cc09765c
ISSN
1359-7345
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BME_Journal Papers
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