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DC Field | Value | Language |
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dc.citation.endPage | 381 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 375 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 19 | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Hwang, Jong-Ik | - |
dc.contributor.author | Choi, Jung-Woong | - |
dc.contributor.author | Kim, Daesoo | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.contributor.author | Shin, Kum-Joo | - |
dc.contributor.author | Oh, Yong-Seok | - |
dc.contributor.author | Lee, Zee-Won | - |
dc.contributor.author | Ha, Kwon-Soo | - |
dc.contributor.author | Shin, Hee-Sup | - |
dc.date.accessioned | 2023-12-22T10:36:18Z | - |
dc.date.available | 2023-12-22T10:36:18Z | - |
dc.date.created | 2015-01-16 | - |
dc.date.issued | 2005-06 | - |
dc.description.abstract | Phospholipase C-β (PLC-β) hydrolyses phosphatidylinositol 4,5-bisphosphate and generates inositol 1,4,5-trisphosphate in response to activation of various G protein-coupled receptors (GPCRs). Using glial cells from knock-out mice lacking either PLC-β1 [PLC-β1 (-/-)] or PLC-β3 [PLC-β3 (-/-)], we examined which isotype of PLC- participated in the cellular signaling events triggered by thrombin. Generation of inositol phosphates (IPs) was enhanced by thrombin in PLC-β1 (-/-) cells, but was negligible in PLC-β3 (-/-) cells. Expression of PLC-β in PLC-β(-/-) cells resulted in an increase in pertussis toxin (PTx)-sensitive IPs in response to thrombin as well as to PARI-specific peptide, while expression of PLC-β1 in PLC-β1 (-/-) cells did not have any effect on IP generation. The thrombin-induced [Ca2+]i increase was delayed and attenuated in PLC-β3 (-/-) cells, but normal in PLC-β1 (-/-) cells. Pertussis toxin evoked a delayed [Ca2+], increase in PLC-β3 (-/-) cells as well as in PLC-β1 (-/-) cells. These results suggest that activation of PLC-β3 by pertussis toxin-sensitive G proteins is responsible for the transient [Ca2+], increase in response to thrombin, whereas the delayed [Ca2+], increase may be due to activation of some other PLC, such as PLC-β4, acting via PTx-insensitive G proteins. | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.19, no.3, pp.375 - 381 | - |
dc.identifier.doi | 10.1016/j.atherosclerosis.2004.12.046 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.scopusid | 2-s2.0-27244445213 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/10827 | - |
dc.identifier.wosid | 000231331100020 | - |
dc.language | 영어 | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | Phospholipase C-β3 mediates the thrombin-induced Ca2+ response in glial cells | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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