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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Multiple roles of phosphoinositide-specific phospholipase C isozymes

Cited 193 times inthomson ciCited 200 times inthomson ci
Title
Multiple roles of phosphoinositide-specific phospholipase C isozymes
Author
Suh, Pann-GhillPark, Jae-IlManzoli, LuciaCocco, LucioPeak, Joanna C.Katan, MatildaFukami, KiyokoKataoka, TohruYun, SangukRyu, Sung Ho
Issue Date
2008-06
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Citation
BMB REPORTS, v.41, no.6, pp.415 - 434
Abstract
Phosphoinositide-specific phospholipase C is an effector molecule in the signal transduction process. It generates two second messengers, inositol-1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. Currently, thirteen mammal PLC isozymes have been identified, and they are divided into six groups: PLC-beta, -gamma, -delta, -epsilon, -zeta and -eta. Sequence analysis studies demonstrated that each isozyme has more than one alternative splicing variant. PLC isozymes contain the X and Y domains that are responsible for catalytic activity. Several other domains including the PH domain, the C2 domain and EF hand motifs are involved in various biological functions of PLC isozymes as signaling proteins. The distribution of PLC isozymes is tissue and organ specific. Recent studies on isolated cells and knockout mice depleted of PLC isozymes have revealed their distinct phenotypes. Given the specificity in distribution and cellular localization, it is clear that each PLC isozyme bears a unique function in the modulation of physiological responses. In this review, we discuss the structural organization, enzymatic properties and molecular diversity of PLC splicing variants and study functional and physiological roles of each isozyme.
URI
https://scholarworks.unist.ac.kr/handle/201301/10826
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=46249091922
ISSN
1976-6696
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BIO_Journal Papers
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