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Kwon, Hyug Moo
Immunometabolism and Cancer Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorder, Genomic instability

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Tonicity response element binding protein associated with neuronal cell death in the experimental diabetic retinopathy

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dc.contributor.author Kim, Seong-Jae ko
dc.contributor.author Kim, Hwajin ko
dc.contributor.author Park, Jeongsook ko
dc.contributor.author Chung, Inyoung ko
dc.contributor.author Kwon, H. Moo ko
dc.contributor.author Choi, Wan-Sung ko
dc.contributor.author Yoo, Ji-Myong ko
dc.date.available 2015-01-22T00:01:12Z -
dc.date.created 2015-01-20 ko
dc.date.issued 2014-12 ko
dc.identifier.citation INTERNATIONAL JOURNAL OF OPHTHALMOLOGY , v.7, no.6, pp.935 - 940 ko
dc.identifier.issn 2222-3959 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/10230 -
dc.description.abstract AIM: To study the contribution of tonicity response element binding protein (TonEBP) in retinal ganglion cell (RGC) death of diabetic retinopathy (DR). METHODS: Diabetes was induced in C57BL/6 mice by five consecutive intraperitoneal injections of 55 mg/kg streptozotocin (STZ). Control mice received vehicle (phosphate -buffered saline). All mice were killed 2mo after injections, and the extent of cell death and the protein expression levels of TonEBP and aldose reductase (AR) were examined. RESULTS: The TonEBP and AR protein levels and the death of RGC were significantly increased in the retinas of diabetic mice compared with controls 2mo after the induction of diabetes. Terminal deoxynucleotidyl transferase (TdT) -mediated dUTP nick end labeling (TUNEL) -positive signals co -localized with TonEBP immunoreactive RGC. These changes were increased in the diabetic retinas compared with controls. CONCLUSION: The present data show that AR and TonEBP are upregulated in the DR and TonEBP may contribute to apoptosis of RGC in the DR. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher IJO PRESS ko
dc.title Tonicity response element binding protein associated with neuronal cell death in the experimental diabetic retinopathy ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84925452356 ko
dc.identifier.wosid 000346551300004 ko
dc.type.rims ART ko
dc.description.wostc 2 *
dc.description.scopustc 2 *
dc.date.tcdate 2015-12-28 *
dc.date.scptcdate 2015-11-04 *
dc.identifier.doi 10.3980/j.issn.2222-3959.2014.06.04 ko
dc.identifier.url http://www.ijo.cn/gjyken/ch/reader/view_abstract.aspx?file_no=20140604&flag=1 ko
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