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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Compounds stimulating cytosolic phospholipase A(2) activity with a combinational action mode

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Title
Compounds stimulating cytosolic phospholipase A(2) activity with a combinational action mode
Author
Bae, YSPark, EYLee, HYKang, HKSuh, Pann-GhillKwak, JYRyu, SHLee, T
Issue Date
2004-12
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.325, no.2, pp.632 - 638
Abstract
The screening of small synthetic compound libraries is a useful means of identifying molecules that modulate various cellular responses. We screened more than 10,000 different small compounds and identified three synthetic compounds that stimulate arachidonic acid (AA) release in a combinational manner in neutrophil-like differentiated HL60 cells. These three compounds were designated as AARIC-1, -2, and -3, representing AA release inducing compounds-1, -2, and -3. Although AA release was not induced by any single one of these compounds, it was dramatically stimulated by the three compounds in combination. Moreover, the effect of combined treatment by these compounds on AA release was completely abolished by MAFP and AACOCF(3), specific cytosolic phospholipase A(2) inhibitors. Furthermore, we found that AARIC-3 stimulates cytosolic calcium influx, while AARIC-1 induces ERK activation. Taken together, we demonstrate a useful approach to the study of complicated and nonlinear intracellular signaling networks using small synthetic compounds in combination.
URI
https://scholarworks.unist.ac.kr/handle/201301/10178
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=7644224240
DOI
10.1016/j.bbrc.2004.10.063
ISSN
0006-291X
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