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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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C-terminal part of AgRP stimulates insulin secretion through calcium release in pancreatic beta Rin5mf cells

Cited 4 times inthomson ciCited 3 times inthomson ci
Title
C-terminal part of AgRP stimulates insulin secretion through calcium release in pancreatic beta Rin5mf cells
Author
Kim, HSYumkham, SLee, HYCho, JHKim, MHKoh, DSRyu, SHSuh, Pann-Ghill
Keywords
AgRP; calcium; insulin; pancreatic beta cells; phospholipase C
Issue Date
2005-08
Publisher
CHURCHILL LIVINGSTONE
Citation
NEUROPEPTIDES, v.39, no.4, pp.385 - 393
Abstract
Agouti-related protein (AgRP) is an orexigenic peptide which is composed of three parts; the amino (N)-terminus, the middle part, and the carboxyl (C)-terminus. AgRP has been implicated in various cell signaling, but the precise role of each parts are currently unclear. In this study, we have attempted to determine which part of AgRP was critical for insulin secretion. We have found that the C-terminus of AgRP specifically increases the intracellular calcium concentration in pancreatic beta Rin5mf cells in a PLC-dependent manner, whereas the middle part and C-terminus have little effects on calcium release. This calcium response can be observed in the freshly isolated primary P cells also. Moreover, amperometric measurement reveals that the C-terminus of AgRP increases the rate of exocytosis in Rin5mf cells. We further show that this region of AgRP is responsible for insulin secretion in a PLC-dependent manner. Taken together, these results indicate that the C-terminus of AgRP can participate in the insulin secretion in pancreatic P cells, through the modulation of calcium release. (c) 2005 Elsevier Ltd. All rights reserved.
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DOI
10.1016/j.npep.2005.04.005
ISSN
0143-4179
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BME_Journal Papers
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