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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Serum amyloid A binding to formyl peptide receptor-like 1 induces synovial hyperplasia and angiogenesis

Cited 66 times inthomson ciCited 70 times inthomson ci
Title
Serum amyloid A binding to formyl peptide receptor-like 1 induces synovial hyperplasia and angiogenesis
Author
Lee, Mi-SookYoo, Seung-AhCho, Chul-SooSuh, Pann-GhillKim, Wan-UkRyu, Sung Ho
Issue Date
2006-10
Publisher
AMER ASSOC IMMUNOLOGISTS
Citation
JOURNAL OF IMMUNOLOGY, v.177, no.8, pp.5585 - 5594
Abstract
Serum amyloid A (SAA) is a major acute-phase reactant, and has been demonstrated to mediate proinflammatory cellular responses. Although SAA has been used as an indicator for a variety of inflammatory diseases, the role of SAA in synovial hyperplasia and proliferation of endothelial cells, a pathological hallmark of rheumatoid arthritis (RA), has yet to be elucidated. In this study, we have demonstrated that SAA promotes the proliferation of human fibroblast-like synoviocytes (FLS). In addition, SAA protects RA FLS against the apoptotic death induced by serum starvation, anti-Fas IgM, and sodium nitroprusside. The activity of SAA appears to be mediated by the formyl peptide receptor-like 1 (FPRL1) receptor, as it was mimicked by the WKYMVm peptide; a specific ligand for FPRL1, but completely abrogated by down-regulating the FPRL1 transcripts with short interfering RNA. The effect of SAA on FLS hyperplasia was shown to be caused by an increase in the levels of intracellular calcium, as well as the activation of ERK and Akt, which resulted in an elevation in the expression of cyclin D1 and Bcl-2. Moreover, SAA stimulated the proliferation, migration, and tube formation of endothelial cells in vitro, and enhanced the sprouting activity of endothelial cells ex vivo and neovascularization in vivo. These observations indicate that the binding of SAA to FPRL1 may contribute to the destruction of bone and cartilage via the promotion of synoviocyte hyperplasia and angiogenesis, thus providing a potential target for the control of RA.
URI
https://scholarworks.unist.ac.kr/handle/201301/10123
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33749529307
ISSN
0022-1767
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BIO_Journal Papers
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