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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Lysophosphatidic acid regulates blood glucose by stimulating myotube and adipocyte glucose uptake

Cited 19 times inthomson ciCited 21 times inthomson ci
Title
Lysophosphatidic acid regulates blood glucose by stimulating myotube and adipocyte glucose uptake
Author
Yea, KyungmooKim, JaeyoonLim, SeyoungPark, Ho SeonPark, Kyong SooSuh, Pann-GhillRyu, Sung Ho
Issue Date
2008-02
Publisher
SPRINGER
Citation
JOURNAL OF MOLECULAR MEDICINE-JMM, v.86, no.2, pp.211 - 220
Abstract
Lysophosphatidic acid (LPA) is known to have diverse cellular effects, but although LPA is present in many biological fluids, including blood, its effects on glucose metabolism have not been elucidated. In this study, we investigated whether LPA stimulation is related to glucose regulation. LPA was found to enhance glucose uptake in a dose-dependent manner both in L6 GLUT4myc myotubes and 3T3-L1 adipocytes by triggering GLUT4 translocation to the plasma membrane. Moreover, the effect of LPA on glucose uptake was completely inhibited by pretreating both cells with LPA receptor antagonist Ki16425 and G(i) inhibitor pertussis toxin. In addition, LPA increased the phosphorylation of AKT-1 with no effects on IRS-1, and LPA-induced glucose uptake was abrogated by pretreatment with the PI 3-kinase inhibitor LY294002. When low concentration of insulin and LPA were treated simultaneously, an additive effect on glucose uptake was observed in both cell types. In line with its cellular functions, LPA significantly lowered blood glucose levels in normal mice but did not affect insulin secretion. LPA also had a glucose-lowering effect in streptozotocin-treated type 1 diabetic mice. In combination, these results suggest that LPA is involved in the regulation of glucose homeostasis in muscle and adipose tissues.0
URI
https://scholarworks.unist.ac.kr/handle/201301/10099
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=38649086101
DOI
10.1007/s00109-007-0269-z
ISSN
0946-2716
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BIO_Journal Papers
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