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DC Field | Value | Language |
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dc.citation.endPage | 1826 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1818 | - |
dc.citation.title | CELLULAR SIGNALLING | - |
dc.citation.volume | 21 | - |
dc.contributor.author | Chae, Young Chan | - |
dc.contributor.author | Lee, Sukmook | - |
dc.contributor.author | Heo, Kyun | - |
dc.contributor.author | Ha, Sang Hoon | - |
dc.contributor.author | Jung, Yonwoo | - |
dc.contributor.author | Kim, Jong Hyun | - |
dc.contributor.author | Ihara, Yasuo | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.date.accessioned | 2023-12-22T07:37:04Z | - |
dc.date.available | 2023-12-22T07:37:04Z | - |
dc.date.created | 2015-01-12 | - |
dc.date.issued | 2009-12 | - |
dc.description.abstract | Collapsin response mediator protein-2 (CRMP-2) plays a key role in axonal development by regulating microtubule dynamics. However, the molecular mechanisms underlying this function have not been clearly elucidated. In this study, we demonstrated that hCRMP-2, specifically amino acid residues 480-509, is essential for stimulating tubulin GTPase activity. We also found that the GTPase-activating protein (GAP) activity of hCRMP-2 was important for microtubule assembly and neurite formation in differentiated PC12 pheochromocytoma cell lines. Mutant hCRMP-2, lacking arginine residues responsible for GAP activity, inhibited microtubule assembly and neurite formation. Interestingly, we found that the N-terminal region (amino acids 150-299) of hCRMP-2 had an inhibitory role on GAP activity via a direct interaction with the C-terminal region (amino acids 480-509). Our results suggest that CRMP-2 as a tubulin direct binder may be a GAP of tubulin in neurite formation and that its CAP activity may be regulated by an intramolecular interaction with an N-terminal inhibitory region. | - |
dc.identifier.bibliographicCitation | CELLULAR SIGNALLING, v.21, no.12, pp.1818 - 1826 | - |
dc.identifier.doi | 10.1016/j.cellsig.2009.07.017 | - |
dc.identifier.issn | 0898-6568 | - |
dc.identifier.scopusid | 2-s2.0-70349784226 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/10095 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70349784226 | - |
dc.identifier.wosid | 000271269900011 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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