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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity

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dc.contributor.author Chae, Young Chan ko
dc.contributor.author Lee, Sukmook ko
dc.contributor.author Heo, Kyun ko
dc.contributor.author Ha, Sang Hoon ko
dc.contributor.author Jung, Yonwoo ko
dc.contributor.author Kim, Jong Hyun ko
dc.contributor.author Ihara, Yasuo ko
dc.contributor.author Suh, Pann-Ghill ko
dc.contributor.author Ryu, Sung Ho ko
dc.date.available 2015-01-13T00:29:25Z -
dc.date.created 2015-01-12 ko
dc.date.issued 2009-12 ko
dc.identifier.citation CELLULAR SIGNALLING, v.21, no.12, pp.1818 - 1826 ko
dc.identifier.issn 0898-6568 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/10095 -
dc.description.abstract Collapsin response mediator protein-2 (CRMP-2) plays a key role in axonal development by regulating microtubule dynamics. However, the molecular mechanisms underlying this function have not been clearly elucidated. In this study, we demonstrated that hCRMP-2, specifically amino acid residues 480-509, is essential for stimulating tubulin GTPase activity. We also found that the GTPase-activating protein (GAP) activity of hCRMP-2 was important for microtubule assembly and neurite formation in differentiated PC12 pheochromocytoma cell lines. Mutant hCRMP-2, lacking arginine residues responsible for GAP activity, inhibited microtubule assembly and neurite formation. Interestingly, we found that the N-terminal region (amino acids 150-299) of hCRMP-2 had an inhibitory role on GAP activity via a direct interaction with the C-terminal region (amino acids 480-509). Our results suggest that CRMP-2 as a tubulin direct binder may be a GAP of tubulin in neurite formation and that its CAP activity may be regulated by an intramolecular interaction with an N-terminal inhibitory region. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher ELSEVIER SCIENCE INC ko
dc.title Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-70349784226 ko
dc.identifier.wosid 000271269900011 ko
dc.type.rims ART ko
dc.description.wostc 25 *
dc.description.scopustc 27 *
dc.date.tcdate 2015-12-28 *
dc.date.scptcdate 2015-11-04 *
dc.identifier.doi 10.1016/j.cellsig.2009.07.017 ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70349784226 ko
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