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A novel TRAP1 inhibitor, containing flexible triphenylphosphonium, interacted with an allosteric site involving E403 residue and triggered protein conformational changes

Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2018-10-20 View80

A novel TRAP1 inhibitor, UB-010 potently inactivates the mitochondrial chaperoneby interacting with the client binding site.

Yoon, Nam Gu , Hu, Sung , Kim. So-Yeon , Lee, Changwook , Kang, Byoung Heon

Conference Paper Issue Date2020-10-08 View80

Anticancer strategy targeting mitochondrial Hsp90 in breast tumor envionment

Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2023-09-15 View67

Anticancer strategy targeting the tumor microenvironment and development of potent TRAP1 inhibitors File

Yoon, Nam Gu

Thesis Issue Date2022-02 View92

Chemical approaches to development of mitochondrial-targeted Hsp90 inhibitor as anti-cancer therapeutics: Mechanism and conformational change of mitochondrial Hsp90

Hu, Sung , Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2017-04-03 View80

Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity File

Yang, Sujae , Yoon, Nam Gu , Kim, Dongyoung , Park, Eunsun , Kim, So-Yeon , Lee, Ji Hoon , Lee, Changwook , Kang, Byoung Heon , Kang, Soosung

Article Issue Date2021-07 View142

Development of a Fluorescence Probe for High-Throughput Screening of Allosteric Inhibitors Targeting TRAP1 File

Yoon, Nam Gu , Choi, Danbi , Lee, Ji Hye , Kim, So-Yeon , Im, Jin Young , Yun, Jisu , Yang, Sujae , Kim, Taeeun , Kang, Soosung , Kang, Byoung Heon

Article Issue Date2024-12 View113

Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models File

Kim, Darong , Kim, So-Yeon , Kim, Dongyoung , Yoon, Nam Gu , Yun, Jisu , Hong, Ki Bum , Lee, Changwook , Lee, Ji Hoon , Kang, Byoung Heon , Kang, Soosung

Article Issue Date2020-08 View166

Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1 File

Jung, Sejin , Yoon, Nam Gu , Yang, Sujae , Kim, Darong , Lee, Won Seok , Hong, Ki Bum , Lee, Changwook , Kang, Byoung Heon , Lee, Ji Hoon , Kang, Soosung

Article Issue Date2020-01 View170

Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug File

Hu, Sung , Ferraro, Mariarosaria , Thomas, Ajesh P. , Chung, Jeong Min , Yoon, Nam Gu , Seol, Ji-Hoon , Kim, Sangpil , Kim, Han-Ul , An, Mi Young , Ok, Haewon , et al

Article Issue Date2020-03 View174

Function of mitochondrial HSP90 in tumor angiogenesis

Kim, So Yeon , Yoon, Nam Gu , Kim, Eun Hye , Kang, Byoung Heon

Conference Paper Issue Date2020-10-08 View66

Function of mitochondrial HSP90 in tumor microenvironment

Kim, So Yeon , Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2021-12-10 View67

Function of mitochondrial HSP90 in tumor micronenvironment

Kim, So Yeon , Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2021-08-25 View72

Function of the mitochondrial chaperone in ischemic retinopathy.

Kim, So-Yeon , Yoon, Nam Gu , Kang, Byoung Heon , Park, Dong Ho

Conference Paper Issue Date2023-09-15 View74

Function of the mitochondrial chaperone TRAP1 in ischemic retinopathy

Kim, So Yeon , Yoon, Nam Gu , Im, Jin Young , Kim, Juhee , Jeon, Yu Jin , Choi, Young Jae , Lee, Jong-Hwa , Uemura, Akiyoshi , Kang, Byoung Heon , Park, Dong Ho

Conference Paper Issue Date2023-10-28 View95

Mitochondrial chaperone TRAP1 is essential for pathologic vascular changes in ischemic retinopathy

Kim, So-Yeon , Yoon, Nam Gu , Lee, Ji hye , Kim, Jaeho , Yeom, Sun A , Park, Dong Ho , Kang, Byoung Heon

Conference Paper Issue Date2023-09-21 View52

MitoQ inactivates mitochondrial chaperone TRAP1 by interacting with the client binding site

Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2021-12-10 View63

Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site File

Yoon, Nam Gu , Lee, Hakbong , Kim, So-Yeon , Hu, Sung , Kim, Darong , Yang, Sujae , Hong, Ki Bum , Lee, Ji Hoon , Kang, Soosung , Kim, Byung-Gyu , et al

Article Issue Date2021-12 View186

Pro-tumorigenic function of cancer-associated adipocytes depends on the mitochondrial chaperone, TRAP1

Yoon, Nam Gu , Kim, So-Yeon , Kong, Sun-Young , Kang, Byoung Heon

Conference Paper Issue Date2023-09-21 View82

Pseudohypoxic stabilization of HIF1α via cyclophilin D suppression promotes melanoma metastasis File

Park, Hye-Kyung , Hu, Sung , Kim, So Yeon , Yoon, Sora , Yoon, Nam Gu , Lee, Ji Hye , Choi, Wonyoung , Kong, Sun-Young , Kim, Jong Heon , Nam, Dougu , et al

Article Issue Date2025-07 View130

Quaternary ammonium-based mitochondria targeting anticancer agents with high water solubility File

Kim, Sangpil , Yoon, Nam Gu , Jana, Batakrishna , Kang, Byoung Heon , Ryu, Ja-Hyoung

Article Issue Date2022-03 View157

SMx inactivates mitochondrial chaperone TRAP1 by interacting with the client binding site

Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2021-08-25 View59

Targeting the Mitochondrial Chaperone TRAP1 Alleviates Vascular Pathologies in Ischemic Retinopathy File File

Kim, So‐Yeon , Yoon, Nam Gu , Im, Jin Young , Lee, Ji Hye , Kim, Juhee , Jeon, Yujin , Choi, Young Jae , Lee, Jong‐Hwa , Uemura, Akiyoshi , Park, Dong Ho , et al

Article Issue Date2024-01 View15893

The mitochondrial HSP90 TRAP1 regulate hypoxic tumor microenvironment.

Kim, So Yeon , Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2022-02-17 View73

The mitochondrial HSP90, TRAP1 regulates hypoxic environment via stability of HIF1α.

Kim, So Yeon , Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2022-08-26 View83

The pro-tumorigenic role of cancer-associated adipocytes relies on the mitochondrial chaperone, TRAP1.

Yoon, Nam Gu , Kim, So-yeon , Kang, Byoung Heon

Conference Paper Issue Date2023-10-28 View71

Triphenylphosphonium conjugation to a TRAP1 inhibitor, 2-amino-6--chloro-7,9-dihydro-8H-purin-8-one increases antiproliferative activity File

Yang, Sujae , Yoon, Nam Gu , Park, Min-A , Yun, Jisu , Im, Jin Young , Kang, Byoung Heon , Kang, Soosung

Article Issue Date2022-09 View174

Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1 File File

Park, Hye-Kyung , Yoon, Nam Gu , Lee, Ji-Eun , Hu, Sung , Yoon, Sora , Kim, So Yeon , Hong, Jun-Hee , Nam, Dougu , Chae, Young Chan , Park, Jong Bae , et al

Article Issue Date2020-01 View173

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