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Myung, Kyungjae
Center for Genomic Integrity
Research Interests
  • DNA Replication, DNA Repair, DNA Recombination, DNA Damage Response, cancer, aging

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Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site

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Title
Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site
Author
Yoon, Nam GuLee, HakbongKim, So-YeonHu, SungKim, DarongYang, SujaeHong, Ki BumLee, Ji HoonKang, SoosungKim, Byung-GyuMyung, KyungjaeLee, ChangwookKang, Byoung Heon
Issue Date
2021-12
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.143, no.47, pp.19684 - 19696
Abstract
Heat shock protein 90 (Hsp90) family proteins are molecular chaperones that modulate the functions of various substrate proteins (clients) implicated in pro-tumorigenic pathways. In this study, the mitochondria-targeted antioxidant mitoquinone (MitoQ) was identified as a potent inhibitor of mitochondrial Hsp90, known as a tumor necrosis factor receptor-associated protein 1 (TRAP1). Structural analyses revealed an asymmetric bipartite interaction between MitoQ and the previously unrecognized drug binding sites located in the middle domain of TRAP1, believed to be a client binding region. MitoQ effectively competed with TRAP1 clients, and MitoQ treatment facilitated the identification of 103 TRAP1-interacting mitochondrial proteins in cancer cells. MitoQ and its redox-crippled SB-U014/SB-U015 exhibited more potent anticancer activity in vitro and in vivo than previously reported mitochondria-targeted TRAP1 inhibitors. The findings indicate that targeting the client binding site of Hsp90 family proteins offers a novel strategy for the development of potent anticancer drugs.
URI
https://scholarworks.unist.ac.kr/handle/201301/55119
URL
https://pubs.acs.org/doi/10.1021/jacs.1c07099
DOI
10.1021/jacs.1c07099
ISSN
0002-7863
Appears in Collections:
BIO_Journal Papers
BME_Journal Papers
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