BROWSE

Related Researcher

Author

Min, Kyung-Tai
Molecular & Cellular Neurobiology Lab(Min Lab)
Research Interests
  • Local protein synthesis, learning & memory, behavior, mitochondrial dynamics

ITEM VIEW & DOWNLOAD

Life extension in Drosophila by feeding a drug

Cited 161 times inthomson ciCited 155 times inthomson ci
Title
Life extension in Drosophila by feeding a drug
Author
Kang, HLBenzer, SMin, Kyung-Tai
Keywords
HISTONE DEACETYLASE;  GENE-EXPRESSION;  CAENORHABDITIS-ELEGANS;  SUPEROXIDE-DISMUTASE;  OXIDATIVE STRESS;  EXTENDED LIFE;  SPAN;  MELANOGASTER;  OVEREXPRESSION;  MUTANT
Issue Date
200201
Publisher
NATL ACAD SCIENCES
Citation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.99, no.2, pp.838 - 843
Abstract
We report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or reproductive ability. Treatment for a limited period, either early or late in adult life, is also effective. Flies fed PBA show a global increase in histone acetylation as well as a dramatically altered pattern of gene expression, including induction or repression of numerous genes. The delay in aging may result from the altered physiological state.
URI
http://scholarworks.unist.ac.kr/handle/201301/6004
DOI
http://dx.doi.org/10.1073/pnas.022631999
ISSN
0027-8424
Appears in Collections:
SLS_Journal Papers
Files in This Item:
There are no files associated with this item.

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qr_code

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU