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- Suh, Pann-Ghill
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TRANSCRIPTIONAL REGULATION OF PHOSPHOLIPASE C-GAMMA-1 GENE DURING MUSCLE DIFFERENTIATION
- Author(s)
- LEE, SJ, LEE, YH, KIM, YS, RYU, SH, Suh, Pann-Ghill
- Issued Date
- 1995-01
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.206, no.1, pp.194 - 200
- Abstract
- Phospholipase C (PLC) has been known to be a key effector protein in signal transduction pathway for cell proliferation and differentiation. Here, we report the transcriptional regulation of PLC-γ1 during myogenic differentiation. Both PLC-γ1 mRNA and protein levels were increased during myogenesis. The activity of PLC-γ1 was also comparable to the amount estimated by Western blot. Comparing promoter activities of various PLC-γ1 gene upstream regions in myoblast and myotube, the responsible region was mapped between -551 and -480. From these results, we conclude that the transcription of PLC-γ1 is increased by the control of GPE1 region of PLC-γ1 gene during myogenesis.
- Publisher
- ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
- ISSN
- 0006-291X
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