TRANSCRIPTIONAL REGULATION OF PHOSPHOLIPASE C-GAMMA-1 GENE DURING MUSCLE DIFFERENTIATION
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- TRANSCRIPTIONAL REGULATION OF PHOSPHOLIPASE C-GAMMA-1 GENE DURING MUSCLE DIFFERENTIATION
- LEE, SJ; LEE, YH; KIM, YS; RYU, SH; Suh, Pann-Ghill
- PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE; PROMOTER REGION; BOVINE BRAIN; C ISOZYMES; PROTEIN; LOCALIZATION; HYDROLYSIS; BINDING; GAMMA
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- ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.206, no.1, pp.194 - 200
- Phospholipase C (PLC) has been known to be a key effector protein in signal transduction pathway for cell proliferation and differentiation. Here, we report the transcriptional regulation of PLC-γ1 during myogenic differentiation. Both PLC-γ1 mRNA and protein levels were increased during myogenesis. The activity of PLC-γ1 was also comparable to the amount estimated by Western blot. Comparing promoter activities of various PLC-γ1 gene upstream regions in myoblast and myotube, the responsible region was mapped between -551 and -480. From these results, we conclude that the transcription of PLC-γ1 is increased by the control of GPE1 region of PLC-γ1 gene during myogenesis.
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