Phospholipase C-gamma 1 involved in brain disorders
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- Phospholipase C-gamma 1 involved in brain disorders
- Jang, Hyun-Jun; Yang, Yong Ryoul; Kim, Jung Kuk; Choi, Jang Hyun; Seo, Young-Kyo; Lee, Yong Hwa; Lee, Jeung Eun; Ryu, Sung Ho; Suh, Pann-Ghill
- Issue Date
- ADVANCES IN BIOLOGICAL REGULATION, v.53, no.1, pp.51 - 62
- Phosphoinositide-specific phospholipase C-γ1 (PLC-γ1) is an important signaling regulator involved in various cellular processes. In brain, PLC-γ1 is highly expressed and participates in neuronal cell functions mediated by neurotrophins. Consistent with essential roles of PLC-γ1, it is involved in development of brain and synaptic transmission. Significantly, abnormal expression and activation of PLC-γ1 appears in various brain disorders such as epilepsy, depression, Huntington's disease and Alzheimer's disease. Thus, PLC-γ1 has been implicated in brain functions as well as related brain disorders. In this review, we discuss the roles of PLC-γ1 in neuronal functions and its pathological relevance to diverse brain diseases.
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