File Download
There are no files associated with this item.
SFX Link
- Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
- Choi, Jang Hyun
- Lab of Diabetes and Metabolism Lab.
Views & Downloads
Detailed Information
Cited time in 
Cited time in 
Cited time in
Metadata Downloads
Phospholipase C-gamma 1 involved in brain disorders
- Author(s)
- Jang, Hyun-Jun, Yang, Yong Ryoul, Kim, Jung Kuk, Choi, Jang Hyun, Seo, Young-Kyo, Lee, Yong Hwa, Lee, Jeung Eun, Ryu, Sung Ho, Suh, Pann-Ghill
- Issued Date
- 2013-01
- Citation
- ADVANCES IN BIOLOGICAL REGULATION, v.53, no.1, pp.51 - 62
- Abstract
- Phosphoinositide-specific phospholipase C-γ1 (PLC-γ1) is an important signaling regulator involved in various cellular processes. In brain, PLC-γ1 is highly expressed and participates in neuronal cell functions mediated by neurotrophins. Consistent with essential roles of PLC-γ1, it is involved in development of brain and synaptic transmission. Significantly, abnormal expression and activation of PLC-γ1 appears in various brain disorders such as epilepsy, depression, Huntington's disease and Alzheimer's disease. Thus, PLC-γ1 has been implicated in brain functions as well as related brain disorders. In this review, we discuss the roles of PLC-γ1 in neuronal functions and its pathological relevance to diverse brain diseases.
- Publisher
- ELSEVIER
- ISSN
- 2212-4926
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.