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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Phospholipase C-gamma 1 involved in brain disorders

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Title
Phospholipase C-gamma 1 involved in brain disorders
Author
Jang, Hyun-JunYang, Yong RyoulKim, Jung KukChoi, Jang HyunSeo, Young-KyoLee, Yong HwaLee, Jeung EunRyu, Sung HoSuh, Pann-Ghill
Issue Date
201301
Publisher
ELSEVIER
Citation
ADVANCES IN BIOLOGICAL REGULATION, v.53, no.1, pp.51 - 62
Abstract
Phosphoinositide-specific phospholipase C-γ1 (PLC-γ1) is an important signaling regulator involved in various cellular processes. In brain, PLC-γ1 is highly expressed and participates in neuronal cell functions mediated by neurotrophins. Consistent with essential roles of PLC-γ1, it is involved in development of brain and synaptic transmission. Significantly, abnormal expression and activation of PLC-γ1 appears in various brain disorders such as epilepsy, depression, Huntington's disease and Alzheimer's disease. Thus, PLC-γ1 has been implicated in brain functions as well as related brain disorders. In this review, we discuss the roles of PLC-γ1 in neuronal functions and its pathological relevance to diverse brain diseases.
URI
http://scholarworks.unist.ac.kr/handle/201301/3168
DOI
http://dx.doi.org/10.1016/j.jbior.2012.09.008
ISSN
2212-4926
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