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- Myung, Kyungjae
- Center for Genomic Integrity
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Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination
- Author(s)
- De Piccoli, Giacomo, Cortes-Ledesma, Felipe, Ira, Gregory, Torres-Rosell, Jordi, Uhle, Stefan, Farmer, Sarah, Hwang, Ji-Young, Machin, Felix, Ceschia, Audrey, McAleenan, Alexandra, Cordon-Preciado, Violeta, Clemente-Blanco, Andres, Vilella-Mitjana, Felip, Ullal, Pranav, Jarmuz, Adam, Leitao, Beatriz, Bressan, Debra, Dotiwala, Farokh, Papusha, Alma, Zhao, Xiaolan, Myung, Kyungjae, Haber, James E., Aguilera, Andres, Aragon, Luis
- Issued Date
- 2006-09
- DOI
- 10.1038/ncb1466
- Citation
- NATURE CELL BIOLOGY, v.8, no.9, pp.1032 - U118
- Abstract
- DNA double-strand breaks (DSB) can arise during DNA replication, or after exposure to DNA-damaging agents, and their correct repair is fundamental for cell survival and genomic stability. Here, we show that the Smc5-Smc6 complex is recruited to DSBs de novo to support their repair by homologous recombination between sister chromatids. In addition, we demonstrate that Smc5-Smc6 is necessary to suppress gross chromosomal rearrangements. Our findings show that the Smc5-Smc6 complex is essential for genome stability as it promotes repair of DSBs by error-free sisterchromatid recombination (SCR), thereby suppressing inappropriate non-sister recombination events.
- Publisher
- NATURE PUBLISHING GROUP
- ISSN
- 1465-7392
- Keyword
- SACCHAROMYCES-CEREVISIAE, YEAST, COHESIN, REGIONS, GENES
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