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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Deacetylated alpha beta-tubulin acts as a positive regulator of Rheb GTPase through increasing its GTP-loading

Cited 3 times inthomson ciCited 2 times inthomson ci
Title
Deacetylated alpha beta-tubulin acts as a positive regulator of Rheb GTPase through increasing its GTP-loading
Author
Lee, Mi NamKoh, AraPark, DohyunJang, Jin-HyeokKwak, DongohJeon, HyeonaKim, JaeyoonChoi, Eun-JeongJeong, HeeyoonSuh, Pann-GhillRyu, Sung Ho
Keywords
Mitosis; MTOR; Rheb; Soluble tubulin
Issue Date
201302
Publisher
ELSEVIER SCIENCE INC
Citation
CELLULAR SIGNALLING, v.25, no.2, pp.539 - 551
Abstract
Ras homolog enriched in brain (Rheb) regulates diverse cellular functions by modulating its nucleotide-bound status. Although Rheb contains a high basal GTP level, the regulatory mechanism of Rheb is not well understood. In this study, we propose soluble alpha beta-tubulin acts as a constitutively active Rheb activator, which may explain the reason why Rheb has a high basal GTP levels. We found that soluble alpha beta-tubulin is a direct Rheb-binding protein and that its deacetylated form has a high binding affinity for Rheb. Modulation of both soluble and acetylated alpha beta-tubulin levels affects the level of GTP-bound Rheb. This occurs in the mitotic phase in which the level of acetylated alpha beta-tubulin is increased but that of GTP-bound Rheb is decreased. Constitutively active Rheb-overexpressing cells showed an abnormal mitotic progression, suggesting the deacetylated alpha beta-tubulin-mediated regulation of Rheb status may be important for proper mitotic progression. Taken together, we propose that deacetylated soluble alpha beta-tubulin is a novel type of positive regulator of Rheb and may play a role as a temporal regulator for Rheb during the cell cycle.
URI
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DOI
http://dx.doi.org/10.1016/j.cellsig.2012.11.006
ISSN
0898-6568
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