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Author

Soper, Steven A.
Soper Research Group
Research Interests
  • Micro- and nano-fabrication

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Complete plastic nanofluidic devices for DNA analysis via direct imprinting with polymer stamps

Cited 13 times inthomson ciCited 10 times inthomson ci
Title
Complete plastic nanofluidic devices for DNA analysis via direct imprinting with polymer stamps
Author
Wu, JiahaoChantiwas, RattikanAmirsadeghi, AlborzSoper, Steven A.Park, Sunggook
Keywords
CHANNELS; NANOCHANNELS; FABRICATION; LITHOGRAPHY; MOLECULES; FLOW
Issue Date
201111
Publisher
ROYAL SOC CHEMISTRY
Citation
LAB ON A CHIP, v.11, no.17, pp.2984 - 2989
Abstract
Development of all polymer-based nanofluidic devices using replication technologies, which is a prerequisite for providing devices for a larger user base, is hampered by undesired substrate deformation associated with the replication of multi-scale structures. Therefore, most nanofluidic devices have been fabricated in glass-like substrates or in a polymer resist layer coated on a substrate. This letter presents a rapid, high fidelity direct imprinting process to build polymer nanofluidic devices in a single step. Undesired substrate deformation during imprinting was significantly reduced through the use of a polymer stamp made from a UV-curable resin. The integrity of the enclosed all polymer-based nanofluidic system was verified by a fluorescein filling experiment and translocation/ stretching of lambda-DNA molecules through the nanochannels. It was also found that the funnel-like design of the nanochannel inlet significantly improved the entrance of DNA molecules into nanochannels compared to an abrupt nanochannel/microfluidic network interface.
URI
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DOI
http://dx.doi.org/10.1039/c1lc20294d
ISSN
1473-0197
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