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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Wnt5a stimulates chemotactic migration and chemokine production in human neutrophils

Cited 4 times inthomson ciCited 4 times inthomson ci
Title
Wnt5a stimulates chemotactic migration and chemokine production in human neutrophils
Author
Jung, Young SuLee, Ha YoungKim, Sang DooPark, Joon SeongKim, Jung KukSuh, Pann-GhillBae, Yoe-Sik
Keywords
Chemotaxis; Gi-protein coupled receptor; Neutrophils; Wnt5a
Issue Date
201306
Publisher
NATURE PUBLISHING GROUP
Citation
EXPERIMENTAL AND MOLECULAR MEDICINE, v.45, no.6, pp.1 - 8
Abstract
Wnt5a is a ligand that activates the noncanonical Wnt signaling pathways (β-catenin-independent pathways). Human neutrophils expressed several Wnt5a receptors, such as Frizzled 2, 5 and 8. Stimulation of human neutrophils with Wnt5a caused chemotactic migration and the production of two important chemokines, CXCL8 and CCL2. CCL2 production by Wnt5a was mediated by a pertussis toxin-sensitive G-protein-dependent pathway. Wnt5a also stimulated the phosphorylation of three mitogen-activated protein kinases (MAPKs: ERK, p38 MAPK and JNK) and Akt. Inhibition of ERK, p38 MAPK or JNK by specific inhibitors induced a dramatic reduction in Wnt5a-induced CCL2 production. Supernatant collected from lipopolysaccharide-stimulated macrophages induced neutrophil chemotaxis, which was significantly inhibited by anti-Wnt5a antibody. Our results suggested that Wnt5a may contribute to neutrophil recruitment, mediating the inflammation response.
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DOI
http://dx.doi.org/10.1038/emm.2013.48
ISSN
1226-3613
Appears in Collections:
SLS_Journal Papers
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