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Suh, Pann-Ghill
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dc.citation.endPage 8 -
dc.citation.number 6 -
dc.citation.startPage 1 -
dc.citation.title EXPERIMENTAL AND MOLECULAR MEDICINE -
dc.citation.volume 45 -
dc.contributor.author Jung, Young Su -
dc.contributor.author Lee, Ha Young -
dc.contributor.author Kim, Sang Doo -
dc.contributor.author Park, Joon Seong -
dc.contributor.author Kim, Jung Kuk -
dc.contributor.author Suh, Pann-Ghill -
dc.contributor.author Bae, Yoe-Sik -
dc.date.accessioned 2023-12-22T03:46:06Z -
dc.date.available 2023-12-22T03:46:06Z -
dc.date.created 2013-08-27 -
dc.date.issued 2013-06 -
dc.description.abstract Wnt5a is a ligand that activates the noncanonical Wnt signaling pathways (β-catenin-independent pathways). Human neutrophils expressed several Wnt5a receptors, such as Frizzled 2, 5 and 8. Stimulation of human neutrophils with Wnt5a caused chemotactic migration and the production of two important chemokines, CXCL8 and CCL2. CCL2 production by Wnt5a was mediated by a pertussis toxin-sensitive G-protein-dependent pathway. Wnt5a also stimulated the phosphorylation of three mitogen-activated protein kinases (MAPKs: ERK, p38 MAPK and JNK) and Akt. Inhibition of ERK, p38 MAPK or JNK by specific inhibitors induced a dramatic reduction in Wnt5a-induced CCL2 production. Supernatant collected from lipopolysaccharide-stimulated macrophages induced neutrophil chemotaxis, which was significantly inhibited by anti-Wnt5a antibody. Our results suggested that Wnt5a may contribute to neutrophil recruitment, mediating the inflammation response. -
dc.identifier.bibliographicCitation EXPERIMENTAL AND MOLECULAR MEDICINE, v.45, no.6, pp.1 - 8 -
dc.identifier.doi 10.1038/emm.2013.48 -
dc.identifier.issn 1226-3613 -
dc.identifier.scopusid 2-s2.0-84881192008 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/2520 -
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84881192008 -
dc.identifier.wosid 000321185500002 -
dc.language 영어 -
dc.publisher NATURE PUBLISHING GROUP -
dc.title Wnt5a stimulates chemotactic migration and chemokine production in human neutrophils -
dc.type Article -
dc.relation.journalWebOfScienceCategory Biochemistry & Molecular Biology; Medicine, Research & Experimental -
dc.relation.journalResearchArea Biochemistry & Molecular Biology; Research & Experimental Medicine -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor chemotaxis -
dc.subject.keywordAuthor G(i)-protein coupled receptor -
dc.subject.keywordAuthor neutrophils -
dc.subject.keywordAuthor Wnt5a -
dc.subject.keywordPlus NF-KAPPA-B -
dc.subject.keywordPlus CHEMOATTRACTANT PEPTIDES -
dc.subject.keywordPlus LEUKOCYTE RECRUITMENT -
dc.subject.keywordPlus INTERNATIONAL UNION -
dc.subject.keywordPlus IDENTIFICATION -
dc.subject.keywordPlus CELLS -
dc.subject.keywordPlus INFLAMMATION -
dc.subject.keywordPlus PATHWAY -
dc.subject.keywordPlus MACROPHAGES -
dc.subject.keywordPlus INFECTIONS -

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