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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 8 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 45 | - |
dc.contributor.author | Jung, Young Su | - |
dc.contributor.author | Lee, Ha Young | - |
dc.contributor.author | Kim, Sang Doo | - |
dc.contributor.author | Park, Joon Seong | - |
dc.contributor.author | Kim, Jung Kuk | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Bae, Yoe-Sik | - |
dc.date.accessioned | 2023-12-22T03:46:06Z | - |
dc.date.available | 2023-12-22T03:46:06Z | - |
dc.date.created | 2013-08-27 | - |
dc.date.issued | 2013-06 | - |
dc.description.abstract | Wnt5a is a ligand that activates the noncanonical Wnt signaling pathways (β-catenin-independent pathways). Human neutrophils expressed several Wnt5a receptors, such as Frizzled 2, 5 and 8. Stimulation of human neutrophils with Wnt5a caused chemotactic migration and the production of two important chemokines, CXCL8 and CCL2. CCL2 production by Wnt5a was mediated by a pertussis toxin-sensitive G-protein-dependent pathway. Wnt5a also stimulated the phosphorylation of three mitogen-activated protein kinases (MAPKs: ERK, p38 MAPK and JNK) and Akt. Inhibition of ERK, p38 MAPK or JNK by specific inhibitors induced a dramatic reduction in Wnt5a-induced CCL2 production. Supernatant collected from lipopolysaccharide-stimulated macrophages induced neutrophil chemotaxis, which was significantly inhibited by anti-Wnt5a antibody. Our results suggested that Wnt5a may contribute to neutrophil recruitment, mediating the inflammation response. | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.45, no.6, pp.1 - 8 | - |
dc.identifier.doi | 10.1038/emm.2013.48 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.scopusid | 2-s2.0-84881192008 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/2520 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84881192008 | - |
dc.identifier.wosid | 000321185500002 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Wnt5a stimulates chemotactic migration and chemokine production in human neutrophils | - |
dc.type | Article | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Medicine, Research & Experimental | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Research & Experimental Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | chemotaxis | - |
dc.subject.keywordAuthor | G(i)-protein coupled receptor | - |
dc.subject.keywordAuthor | neutrophils | - |
dc.subject.keywordAuthor | Wnt5a | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | CHEMOATTRACTANT PEPTIDES | - |
dc.subject.keywordPlus | LEUKOCYTE RECRUITMENT | - |
dc.subject.keywordPlus | INTERNATIONAL UNION | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | INFECTIONS | - |
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