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Author

Kim, Byeong-Su
Soft and Hybrid Nanomaterials Lab
Research Interests
  • Carbon materials, polymer, Layer-by-Layer (LbL) assembly, hyperbranched polymer, polyglycerol (PG), bio-applications

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Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells

Cited 11 times inthomson ciCited 9 times inthomson ci
Title
Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells
Author
Kim, Kyoung-RanKim, Da-RaeLee, TaeminYhee, Ji YoungKim, Byeong-SuKwon, Ick ChanAhn, Dae-Ro
Keywords
MULTIDRUG-RESISTANCE; DOXORUBICIN; THERAPY; CARRIER
Issue Date
201303
Publisher
ROYAL SOC CHEMISTRY
Citation
CHEMICAL COMMUNICATIONS, v.49, no.20, pp.2010 - 2012
Abstract
A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.
URI
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DOI
http://dx.doi.org/10.1039/c3cc38693g
ISSN
1359-7345
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