BROWSE

Related Researcher

Author

Kim, Jae-Ick
School of Life Sciences
Research Interests

ITEM VIEW & DOWNLOAD

β-Adrenergic signaling is required for the induction of a labile state during memory reconsolidation

Cited 0 times inthomson ciCited 0 times inthomson ci
Title
β-Adrenergic signaling is required for the induction of a labile state during memory reconsolidation
Author
Lim, Chae-SeokKim, Jae-IckKwak, ChuljungLee, JaehyunJang, Eun HaeOh, JihaeKaang, Bong-Kiun
Keywords
Long-term memory;  Reconsolidation;  β-adrenergic signaling;  Propranolol;  Membrane excitability
Issue Date
ACCEPT
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BRAIN RESEARCH BULLETIN, v., no., pp. -
Abstract
Memory reconsolidation is the process by which previously consolidated memories reenter a labile state through reactivation of the memory trace and are actively consolidated through de novo protein synthesis. Although extensive studies have shown that β-adrenergic signaling plays a critical role in the restabilization of reactivated memory, its role in the destabilization of long-term memory is not well-studied. In this study, we found that membrane excitability increased in hippocampal CA1 neurons immediately after the retrieval of contextual fear memory. Interestingly, this increase in membrane excitability diminished after treatment with propranolol (a β-adrenergic receptor antagonist), an NMDA receptor antagonist, and a PKA inhibitor. In addition, we found that administration of propranolol prior to, but not after, the retrieval of fear memory ameliorated the memory impairment caused by anisomycin, indicating that inhibition of β-adrenergic signaling blocks the destabilization of contextual fear memory. Taken together, these results indicate that β-adrenergic signaling via NMDA receptors and PKA signaling pathway induces a labile state of long-term memory through increased neuronal membrane excitability.
URI
Go to Link
DOI
http://dx.doi.org/10.1016/j.brainresbull.2018.04.011
ISSN
0361-9230
Appears in Collections:
SLS_Journal Papers
Files in This Item:
There are no files associated with this item.

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qr_code

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU