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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 57 | - |
dc.citation.startPage | 50 | - |
dc.citation.title | BRAIN RESEARCH BULLETIN | - |
dc.citation.volume | 141 | - |
dc.contributor.author | Lim, Chae-Seok | - |
dc.contributor.author | Kim, Jae-Ick | - |
dc.contributor.author | Kwak, Chuljung | - |
dc.contributor.author | Lee, Jaehyun | - |
dc.contributor.author | Jang, Eun Hae | - |
dc.contributor.author | Oh, Jihae | - |
dc.contributor.author | Kaang, Bong-Kiun | - |
dc.date.accessioned | 2023-12-21T20:38:05Z | - |
dc.date.available | 2023-12-21T20:38:05Z | - |
dc.date.created | 2018-06-19 | - |
dc.date.issued | 2018-07 | - |
dc.description.abstract | Memory reconsolidation is the process by which previously consolidated memories reenter a labile state through reactivation of the memory trace and are actively consolidated through de novo protein synthesis. Although extensive studies have shown that β-adrenergic signaling plays a critical role in the restabilization of reactivated memory, its role in the destabilization of long-term memory is not well-studied. In this study, we found that membrane excitability increased in hippocampal CA1 neurons immediately after the retrieval of contextual fear memory. Interestingly, this increase in membrane excitability diminished after treatment with propranolol (a β-adrenergic receptor antagonist), an NMDA receptor antagonist, and a PKA inhibitor. In addition, we found that administration of propranolol prior to, but not after, the retrieval of fear memory ameliorated the memory impairment caused by anisomycin, indicating that inhibition of β-adrenergic signaling blocks the destabilization of contextual fear memory. Taken together, these results indicate that β-adrenergic signaling via NMDA receptors and PKA signaling pathway induces a labile state of long-term memory through increased neuronal membrane excitability. | - |
dc.identifier.bibliographicCitation | BRAIN RESEARCH BULLETIN, v.141, pp.50 - 57 | - |
dc.identifier.doi | 10.1016/j.brainresbull.2018.04.011 | - |
dc.identifier.issn | 0361-9230 | - |
dc.identifier.scopusid | 2-s2.0-85046158609 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24248 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0361923017303817?via%3Dihub | - |
dc.identifier.wosid | 000442978900008 | - |
dc.language | 영어 | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | β-Adrenergic signaling is required for the induction of a labile state during memory reconsolidation | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Long-term memory | - |
dc.subject.keywordAuthor | Membrane excitability | - |
dc.subject.keywordAuthor | Propranolol | - |
dc.subject.keywordAuthor | Reconsolidation | - |
dc.subject.keywordAuthor | β-adrenergic signaling | - |
dc.subject.keywordPlus | NMDA RECEPTORS | - |
dc.subject.keywordPlus | DESTABILIZATION | - |
dc.subject.keywordPlus | CONDITIONED PLACE PREFERENCE | - |
dc.subject.keywordPlus | POST-RETRIEVAL PROPRANOLOL | - |
dc.subject.keywordPlus | COCAINE-ASSOCIATED MEMORY | - |
dc.subject.keywordPlus | FEAR MEMORIES | - |
dc.subject.keywordPlus | BLOCKS RECONSOLIDATION | - |
dc.subject.keywordPlus | SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | PROTEIN-DEGRADATION | - |
dc.subject.keywordPlus | PREFRONTAL CORTEX | - |
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