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김성진

Kim, Seong-Jin
Bio-inspired Advanced Sensors Lab.
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High-density impedance-sensing array on complementary metal-oxide-semiconductor circuitry assisted by negative dielectrophoresis for single-cell-resolution measurement

Author(s)
Chung, JaehoonChen, YuKim, Seong-Jin
Issued Date
2018-08
DOI
10.1016/j.snb.2018.03.113
URI
https://scholarworks.unist.ac.kr/handle/201301/24008
Fulltext
https://www.sciencedirect.com/science/article/pii/S0925400518306117
Citation
SENSORS AND ACTUATORS B-CHEMICAL, v.266, pp.106 - 114
Abstract
A microarray biosensor that measures the electrical impedance of cell suspensions is presented. Single-cell-resolution measurement was facilitated by physically positioning individual cells on sensing electrodes by dielectrophoresis, obviating chemical or biological surface modification. The high-density (104 x 104) electrode array was incorporated with a complementary metal-oxide-semiconductor (CMOS) integrated chip (IC) to support impedance spectroscopy at frequencies ranging from 100 kHz to 1 MHz, achieving a rapid and cost-effective platform with a small form factor. Experiments with microbeads (10, 15, and 20 mu m in diameter) and a live breast cancer cell line (MCF-7) have demonstrated that the developed prototype quantifies loaded microbeads or cells rapidly (<1 min), with a mapping accuracy over 95%, showing good agreement with optical observation. In addition, a new impedance model of a cancer cell suspended in buffer media was constructed to interpret the measurement results, and the simulation results obtained with the model showed good agreement with the experimental results.
Publisher
ELSEVIER SCIENCE SA
ISSN
0925-4005
Keyword (Author)
Impedance sensorCMOS ICDielectrophoresisHigh-densitySingle-cell resolution2D microelectrode array
Keyword
CMOS ELECTRODE ARRAYON-CHIPSENSORDEVICESBLOOD

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