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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 114 | - |
dc.citation.startPage | 106 | - |
dc.citation.title | SENSORS AND ACTUATORS B-CHEMICAL | - |
dc.citation.volume | 266 | - |
dc.contributor.author | Chung, Jaehoon | - |
dc.contributor.author | Chen, Yu | - |
dc.contributor.author | Kim, Seong-Jin | - |
dc.date.accessioned | 2023-12-21T20:36:38Z | - |
dc.date.available | 2023-12-21T20:36:38Z | - |
dc.date.created | 2018-04-26 | - |
dc.date.issued | 2018-08 | - |
dc.description.abstract | A microarray biosensor that measures the electrical impedance of cell suspensions is presented. Single-cell-resolution measurement was facilitated by physically positioning individual cells on sensing electrodes by dielectrophoresis, obviating chemical or biological surface modification. The high-density (104 x 104) electrode array was incorporated with a complementary metal-oxide-semiconductor (CMOS) integrated chip (IC) to support impedance spectroscopy at frequencies ranging from 100 kHz to 1 MHz, achieving a rapid and cost-effective platform with a small form factor. Experiments with microbeads (10, 15, and 20 mu m in diameter) and a live breast cancer cell line (MCF-7) have demonstrated that the developed prototype quantifies loaded microbeads or cells rapidly (<1 min), with a mapping accuracy over 95%, showing good agreement with optical observation. In addition, a new impedance model of a cancer cell suspended in buffer media was constructed to interpret the measurement results, and the simulation results obtained with the model showed good agreement with the experimental results. | - |
dc.identifier.bibliographicCitation | SENSORS AND ACTUATORS B-CHEMICAL, v.266, pp.106 - 114 | - |
dc.identifier.doi | 10.1016/j.snb.2018.03.113 | - |
dc.identifier.issn | 0925-4005 | - |
dc.identifier.scopusid | 2-s2.0-85044449865 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24008 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0925400518306117 | - |
dc.identifier.wosid | 000430274200012 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCIENCE SA | - |
dc.title | High-density impedance-sensing array on complementary metal-oxide-semiconductor circuitry assisted by negative dielectrophoresis for single-cell-resolution measurement | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation | - |
dc.relation.journalResearchArea | Chemistry; Electrochemistry; Instruments & Instrumentation | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Impedance sensor | - |
dc.subject.keywordAuthor | CMOS IC | - |
dc.subject.keywordAuthor | Dielectrophoresis | - |
dc.subject.keywordAuthor | High-density | - |
dc.subject.keywordAuthor | Single-cell resolution | - |
dc.subject.keywordAuthor | 2D microelectrode array | - |
dc.subject.keywordPlus | CMOS ELECTRODE ARRAY | - |
dc.subject.keywordPlus | ON-CHIP | - |
dc.subject.keywordPlus | SENSOR | - |
dc.subject.keywordPlus | DEVICES | - |
dc.subject.keywordPlus | BLOOD | - |
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