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Kim, Seong-Jin
Bio-inspired Microsystems Lab (BiML)
Research Interests
  • Integrated analog-mixed signal circuit design, semiconductor sensor interface circuits

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High-density impedance-sensing array on complementary metal-oxide-semiconductor circuitry assisted by negative dielectrophoresis for single-cell-resolution measurement

DC FieldValueLanguage
dc.contributor.authorChung, Jaehoonko
dc.contributor.authorChen, Yuko
dc.contributor.authorKim, Seong-Jinko
dc.date.available2018-05-04T00:42:59Z-
dc.date.created2018-04-26ko
dc.date.issued201808ko
dc.identifier.citationSENSORS AND ACTUATORS B-CHEMICAL, v.266, no., pp.106 - 114ko
dc.identifier.issn0925-4005ko
dc.identifier.urihttp://scholarworks.unist.ac.kr/handle/201301/24008-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0925400518306117ko
dc.description.abstractA microarray biosensor that measures the electrical impedance of cell suspensions is presented. Single-cell&#8211;resolution measurement was facilitated by physically positioning individual cells on sensing electrodes by dielectrophoresis, obviating chemical or biological surface modification. The high-density (104&#8239;×&#8239;104) electrode array was incorporated with a complementary metal-oxide-semiconductor (CMOS) integrated chip (IC) to support impedance spectroscopy at frequencies ranging from 100&#8239;kHz to 1&#8239;MHz, achieving a rapid and cost-effective platform with a small form factor. Experiments with microbeads (10, 15, and 20&#8239;μm in diameter) and a live breast cancer cell line (MCF-7) have demonstrated that the developed prototype quantifies loaded microbeads or cells rapidly (<1&#8239;min), with a mapping accuracy over 95%, showing good agreement with optical observation. In addition, a new impedance model of a cancer cell suspended in buffer media was constructed to interpret the measurement results, and the simulation results obtained with the model showed good agreement with the experimental results.ko
dc.languageENGko
dc.publisherELSEVIER SCIENCE SAko
dc.subjectImpedance sensorko
dc.subjectCMOS ICko
dc.subjectDielectrophoresisko
dc.subjectHigh-densityko
dc.subjectSingle-cell resolutionko
dc.subject2D microelectrode arrayko
dc.titleHigh-density impedance-sensing array on complementary metal-oxide-semiconductor circuitry assisted by negative dielectrophoresis for single-cell-resolution measurementko
dc.typeARTICLEko
dc.identifier.pid2581null
dc.identifier.rimsid30196ko
dc.identifier.scopusid2-s2.0-85044449865ko
dc.identifier.wosid000430274200012ko
dc.type.rimsAko
dc.identifier.doihttp://dx.doi.org/10.1016/j.snb.2018.03.113ko
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