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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation

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Title
Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation
Author
Yang, Yong RyoulSong, SeungjuHwang, HongsikJung, Jung HoonKim, Su-JeongYoon, SoraHur, Jin-HoePark, Jae-IlLee, CheolNam, DouguSeo, Young KyoKim, Joung-HunRhim, HyewhonSuh, Pann-Ghill
Issue Date
201704
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v.7, no., pp.44921 -
Abstract
O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O-GlcNAcylation in synaptic function remain unclear. To understand the effect of aberrant O-GlcNAcylation on the brain, we used Oga+/- mice which have an increased level of O-GlcNAcylation, and found that Oga+/- mice exhibited impaired spatial learning and memory. Consistent with this result, Oga+/- mice showed a defect in hippocampal synaptic plasticity. Oga heterozygosity causes impairment of both long-term potentiation and long-term depression due to dysregulation of AMPA receptor phosphorylation. These results demonstrate a role for hyper-O-GlcNAcylation in learning and memory.
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DOI
http://dx.doi.org/10.1038/srep44921
ISSN
2045-2322
Appears in Collections:
SLS_Journal Papers
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