Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation
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- Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation
- Yang, Yong Ryoul; Song, Seungju; Hwang, Hongsik; Jung, Jung Hoon; Kim, Su-Jeong; Yoon, Sora; Hur, Jin-Hoe; Park, Jae-Il; Lee, Cheol; Nam, Dougu; Seo, Young Kyo; Kim, Joung-Hun; Rhim, Hyewhon; Suh, Pann-Ghill
- Issue Date
- NATURE PUBLISHING GROUP
- SCIENTIFIC REPORTS, v.7, no., pp.44921 -
- O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O-GlcNAcylation in synaptic function remain unclear. To understand the effect of aberrant O-GlcNAcylation on the brain, we used Oga+/- mice which have an increased level of O-GlcNAcylation, and found that Oga+/- mice exhibited impaired spatial learning and memory. Consistent with this result, Oga+/- mice showed a defect in hippocampal synaptic plasticity. Oga heterozygosity causes impairment of both long-term potentiation and long-term depression due to dysregulation of AMPA receptor phosphorylation. These results demonstrate a role for hyper-O-GlcNAcylation in learning and memory.
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