Full metadata record
DC Field | Value | Language |
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dc.citation.startPage | 44921 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 7 | - |
dc.contributor.author | Yang, Yong Ryoul | - |
dc.contributor.author | Song, Seungju | - |
dc.contributor.author | Hwang, Hongsik | - |
dc.contributor.author | Jung, Jung Hoon | - |
dc.contributor.author | Kim, Su-Jeong | - |
dc.contributor.author | Yoon, Sora | - |
dc.contributor.author | Hur, Jin-Hoe | - |
dc.contributor.author | Park, Jae-Il | - |
dc.contributor.author | Lee, Cheol | - |
dc.contributor.author | Nam, Dougu | - |
dc.contributor.author | Seo, Young Kyo | - |
dc.contributor.author | Kim, Joung-Hun | - |
dc.contributor.author | Rhim, Hyewhon | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.date.accessioned | 2023-12-21T22:36:24Z | - |
dc.date.available | 2023-12-21T22:36:24Z | - |
dc.date.created | 2017-04-27 | - |
dc.date.issued | 2017-04 | - |
dc.description.abstract | O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O-GlcNAcylation in synaptic function remain unclear. To understand the effect of aberrant O-GlcNAcylation on the brain, we used Oga+/- mice which have an increased level of O-GlcNAcylation, and found that Oga+/- mice exhibited impaired spatial learning and memory. Consistent with this result, Oga+/- mice showed a defect in hippocampal synaptic plasticity. Oga heterozygosity causes impairment of both long-term potentiation and long-term depression due to dysregulation of AMPA receptor phosphorylation. These results demonstrate a role for hyper-O-GlcNAcylation in learning and memory. | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.7, pp.44921 | - |
dc.identifier.doi | 10.1038/srep44921 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.scopusid | 2-s2.0-85016960086 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/21909 | - |
dc.identifier.url | https://www.nature.com/articles/srep44921 | - |
dc.identifier.wosid | 000398105100001 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | LINKED N-ACETYLGLUCOSAMINE | - |
dc.subject.keywordPlus | RECEPTOR GLUR1 SUBUNIT | - |
dc.subject.keywordPlus | GLCNAC MODIFICATION | - |
dc.subject.keywordPlus | MASS-SPECTROMETRY | - |
dc.subject.keywordPlus | AMPA RECEPTOR | - |
dc.subject.keywordPlus | PHOSPHORYLATION SITES | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | AGING BRAIN | - |
dc.subject.keywordPlus | SYNAPSIN I | - |
dc.subject.keywordPlus | PROTEIN | - |
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