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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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PLC-β1 and cell differentiation: An insight into myogenesis and osteogenesis

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Title
PLC-β1 and cell differentiation: An insight into myogenesis and osteogenesis
Author
Ramazzotti, GiuliaFaenza, IreneFiume, RobertaBilli, Anna MariaManzoli, LuciaMongiorgi, SaraRatti, StefanoMcCubrey, James A.Suh, Pann-GhillCocco, LucioFollo, Matilde Y.
Issue Date
201701
Publisher
ELSEVIER SCI LTD
Citation
ADVANCES IN BIOLOGICAL REGULATION, v.63, no., pp.1 - 5
Abstract
Phosphoinositide-phospholipase C-β1 (PLC-β1) plays a crucial role in the initiation of the genetic program responsible for muscle differentiation and osteogenesis. During myogenic differentiation of murine C2C12 myoblasts, PLC-β1 signaling pathway involves the Inositol Polyphosphate Multikinase (IPMK) and β-catenin as downstream effectors. By means of c-jun binding to cyclin D3 promoter, the activation of PLC-β1 pathway determines cyclin D3 accumulation. However, osteogenesis requires PLC-β1 expression and up-regulation but it does not affect cyclin D3 levels, suggesting that the two processes require the activation of different mediators.
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DOI
http://dx.doi.org/10.1016/j.jbior.2016.10.005
ISSN
2212-4926
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