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- Suh, Pann-Ghill
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PLC-β1 and cell differentiation: An insight into myogenesis and osteogenesis
- Author(s)
- Ramazzotti, Giulia, Faenza, Irene, Fiume, Roberta, Billi, Anna Maria, Manzoli, Lucia, Mongiorgi, Sara, Ratti, Stefano, McCubrey, James A., Suh, Pann-Ghill, Cocco, Lucio, Follo, Matilde Y.
- Issued Date
- 2017-01
- Citation
- ADVANCES IN BIOLOGICAL REGULATION, v.63, pp.1 - 5
- Abstract
- Phosphoinositide-phospholipase C-β1 (PLC-β1) plays a crucial role in the initiation of the genetic program responsible for muscle differentiation and osteogenesis. During myogenic differentiation of murine C2C12 myoblasts, PLC-β1 signaling pathway involves the Inositol Polyphosphate Multikinase (IPMK) and β-catenin as downstream effectors. By means of c-jun binding to cyclin D3 promoter, the activation of PLC-β1 pathway determines cyclin D3 accumulation. However, osteogenesis requires PLC-β1 expression and up-regulation but it does not affect cyclin D3 levels, suggesting that the two processes require the activation of different mediators.
- Publisher
- ELSEVIER SCI LTD
- ISSN
- 2212-4926
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