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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 5 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | ADVANCES IN BIOLOGICAL REGULATION | - |
dc.citation.volume | 63 | - |
dc.contributor.author | Ramazzotti, Giulia | - |
dc.contributor.author | Faenza, Irene | - |
dc.contributor.author | Fiume, Roberta | - |
dc.contributor.author | Billi, Anna Maria | - |
dc.contributor.author | Manzoli, Lucia | - |
dc.contributor.author | Mongiorgi, Sara | - |
dc.contributor.author | Ratti, Stefano | - |
dc.contributor.author | McCubrey, James A. | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Cocco, Lucio | - |
dc.contributor.author | Follo, Matilde Y. | - |
dc.date.accessioned | 2023-12-21T22:45:47Z | - |
dc.date.available | 2023-12-21T22:45:47Z | - |
dc.date.created | 2016-12-26 | - |
dc.date.issued | 2017-01 | - |
dc.description.abstract | Phosphoinositide-phospholipase C-β1 (PLC-β1) plays a crucial role in the initiation of the genetic program responsible for muscle differentiation and osteogenesis. During myogenic differentiation of murine C2C12 myoblasts, PLC-β1 signaling pathway involves the Inositol Polyphosphate Multikinase (IPMK) and β-catenin as downstream effectors. By means of c-jun binding to cyclin D3 promoter, the activation of PLC-β1 pathway determines cyclin D3 accumulation. However, osteogenesis requires PLC-β1 expression and up-regulation but it does not affect cyclin D3 levels, suggesting that the two processes require the activation of different mediators. | - |
dc.identifier.bibliographicCitation | ADVANCES IN BIOLOGICAL REGULATION, v.63, pp.1 - 5 | - |
dc.identifier.doi | 10.1016/j.jbior.2016.10.005 | - |
dc.identifier.issn | 2212-4926 | - |
dc.identifier.scopusid | 2-s2.0-85001638618 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/21396 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S2212492616300562 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | PLC-β1 and cell differentiation: An insight into myogenesis and osteogenesis | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.description.journalRegisteredClass | scopus | - |
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