Engineering Gram Selectivity of Mixed-Charge Gold Nanoparticles by Tuning the Balance of Surface Charges
Cited 0 times inCited 0 times in
- Engineering Gram Selectivity of Mixed-Charge Gold Nanoparticles by Tuning the Balance of Surface Charges
- Pillai, Pramod P.; Kowalczyk, Bartlomiej; Kandere-Grzybowska, Kristiana; Borkowska, Magdalena; Grzybowski, Bartosz A.
- antibiotics; Gram specificity; ligands; nanoparticles; surface charge
- Issue Date
- WILEY-V C H VERLAG GMBH
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.55, no.30, pp.8610 - 8614
- Nanoparticles covered with ligand shells comprising both positively and negatively charged ligands exhibit Gram-selective antibacterial action controlled by a single experimental parameter, namely the proportion of [+] and [-] ligands tethered onto these particles. Gram selectivity is attributed to the interplay between polyvalent electrostatic and non-covalent interactions that work in unison to disrupt the bacterial cell wall. The [+/-] nanoparticles are effective in low doses, are non-toxic to mammalian cells, and are tolerated well in mice. These results constitute the first example of rational engineering of Gram selectivity at the (macro) molecular level.
- ; Go to Link
Appears in Collections:
- SNS_Journal Papers
can give you direct access to the published full text of this article. (UNISTARs only)
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.