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Grzybowski, Bartosz A.
School of Natural Science
Research Interests
  • Nano science

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Engineering Gram Selectivity of Mixed-Charge Gold Nanoparticles by Tuning the Balance of Surface Charges

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Title
Engineering Gram Selectivity of Mixed-Charge Gold Nanoparticles by Tuning the Balance of Surface Charges
Author
Pillai, Pramod P.Kowalczyk, BartlomiejKandere-Grzybowska, KristianaBorkowska, MagdalenaGrzybowski, Bartosz A.
Keywords
antibiotics; Gram specificity; ligands; nanoparticles; surface charge
Issue Date
201607
Publisher
WILEY-V C H VERLAG GMBH
Citation
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.55, no.30, pp.8610 - 8614
Abstract
Nanoparticles covered with ligand shells comprising both positively and negatively charged ligands exhibit Gram-selective antibacterial action controlled by a single experimental parameter, namely the proportion of [+] and [-] ligands tethered onto these particles. Gram selectivity is attributed to the interplay between polyvalent electrostatic and non-covalent interactions that work in unison to disrupt the bacterial cell wall. The [+/-] nanoparticles are effective in low doses, are non-toxic to mammalian cells, and are tolerated well in mice. These results constitute the first example of rational engineering of Gram selectivity at the (macro) molecular level.
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DOI
http://dx.doi.org/10.1002/anie.201602965
ISSN
1433-7851
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