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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 8614 | - |
dc.citation.number | 30 | - |
dc.citation.startPage | 8610 | - |
dc.citation.title | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.citation.volume | 55 | - |
dc.contributor.author | Pillai, Pramod P. | - |
dc.contributor.author | Kowalczyk, Bartlomiej | - |
dc.contributor.author | Kandere-Grzybowska, Kristiana | - |
dc.contributor.author | Borkowska, Magdalena | - |
dc.contributor.author | Grzybowski, Bartosz A. | - |
dc.date.accessioned | 2023-12-21T23:37:03Z | - |
dc.date.available | 2023-12-21T23:37:03Z | - |
dc.date.created | 2016-10-07 | - |
dc.date.issued | 2016-07 | - |
dc.description.abstract | Nanoparticles covered with ligand shells comprising both positively and negatively charged ligands exhibit Gram-selective antibacterial action controlled by a single experimental parameter, namely the proportion of [+] and [-] ligands tethered onto these particles. Gram selectivity is attributed to the interplay between polyvalent electrostatic and non-covalent interactions that work in unison to disrupt the bacterial cell wall. The [+/-] nanoparticles are effective in low doses, are non-toxic to mammalian cells, and are tolerated well in mice. These results constitute the first example of rational engineering of Gram selectivity at the (macro) molecular level. | - |
dc.identifier.bibliographicCitation | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.55, no.30, pp.8610 - 8614 | - |
dc.identifier.doi | 10.1002/anie.201602965 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.scopusid | 2-s2.0-84973617961 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/20558 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/anie.201602965/abstract | - |
dc.identifier.wosid | 000383253500020 | - |
dc.language | 영어 | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Engineering Gram Selectivity of Mixed-Charge Gold Nanoparticles by Tuning the Balance of Surface Charges | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | antibiotics | - |
dc.subject.keywordAuthor | Gram specificity | - |
dc.subject.keywordAuthor | ligands | - |
dc.subject.keywordAuthor | nanoparticles | - |
dc.subject.keywordAuthor | surface charge | - |
dc.subject.keywordPlus | ANTIMICROBIAL PEPTIDES | - |
dc.subject.keywordPlus | ELECTROSTATIC TITRATIONS | - |
dc.subject.keywordPlus | POSITIVE BACTERIA | - |
dc.subject.keywordPlus | RATIONAL DESIGN | - |
dc.subject.keywordPlus | POLYMERS | - |
dc.subject.keywordPlus | ANTIBACTERIAL | - |
dc.subject.keywordPlus | ANTIBIOTICS | - |
dc.subject.keywordPlus | STRATEGIES | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | PROTEINS | - |
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