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- Kim, Eunhee
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Simultaneous mitochondrial Ca2+ overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells
- Author(s)
- Yoon, Mi Jin, Kim, Eun Hee, Kwon, Taeg Kyu, Park, Sun Ah, Choi, Kyeong Sook
- Issued Date
- 2012-11
- Citation
- CANCER LETTERS, v.324, no.2, pp.197 - 209
- Abstract
- In this study, we investigated the role of Ca2+ in curcumin-induced paraptosis, a cell death mode that is accompanied by dilation of mitochondria and the endoplasmic reticulum (ER). Curcumin induced mitochondria! Ca2+ overload selectively in the malignant breast cancer cells, but not in the normal breast cell, contributing to the dilation of mitochondria/ER and subsequent paraptotic cell death. In addition, we found that simultaneous inhibition of the mitochondrial Na+/Ca2+ exchanger (mNCX) and proteasomes can trigger a sustained mitochondrial Ca2+ overload and effectively induce paraptosis in malignant breast cancer cells. (C) 2012 Elsevier Ireland Ltd. All rights reserved
- Publisher
- ELSEVIER IRELAND LTD
- ISSN
- 0304-3835
- Keyword (Author)
- Paraptosis, Curcumin, Mitochondrial Ca2+, Proteasomal inhibition, Breast cancer
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